2226941-29-1

2226941-29-1 structure

Name: 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
Chemical Name: 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
CAS Number: 2226941-29-1
Molecular Formula: C₂₈H₂₄N₄O₄
Molecular Weight: 480.51
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2023-12-18 16:45:20
Modify Date: 2024-01-13 06:14:56
3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM[1].

Name	3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

Description	3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
References	[1]. Wang JN, et al. Bioactive Indolocarbazoles from the Marine-Derived Streptomyces sp. DT-A61. J Nat Prod. 2018 Apr 27;81(4):949-956.

Molecular Formula	C₂₈H₂₄N₄O₄
Molecular Weight	480.51