41263-94-9
41263-94-9 structure
- Name: 2'-Fucosyllactose
- Chemical Name: 2′-Fucosyl-D-lactose
- CAS Number: 41263-94-9
- Molecular Formula: C18H32O15
- Molecular Weight: 488.43800
- Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
- Create Date: 2017-01-08 14:00:44
- Modify Date: 2024-01-02 19:45:58
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2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines[1][2].
| Name | 2′-Fucosyl-D-lactose |
|---|---|
| Synonyms | (2R,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanal |
| Description | 2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Target: IFN-γ, IL-6, IL-17, and TNF-α[1] |
| In Vitro | 2'-Fucosyllactose (2'-FL; 0-12 mg/mL; 48 h) suppress cell-associated CD14 expression and to attenuate LPS (100 μg/mL) stimulated IL-8 secretion in T84 cells[1]. 2'-Fucosyllactose (2 mg/mL; 48 h; T84 and HCT8 cells) ameliorates inflammation induced by bacterial invasion. 2'-Fucosyllactose inhibits ETEC invasion and attenuated the consequent IL-8 secretion[1]. 2'-Fucosyllactose (2 mg/mL; 48 h; T84 and HCT8 cells) induces macrophage migration inhibitory factor signal pathways that suppress inflammation[1]. Western Blot Analysis[1] Cell Line: T84 cells Concentration: 0, 2, and 4 mg/mL Incubation Time: 48 hours Result: Suppressed CD14 mRNA and reduced cell-associated CD14 protein expression. Western Blot Analysis[1] Cell Line: T84 and HCT8 cellsT84 and HCT8 cells Concentration: 2 mg/mL Incubation Time: 48 hours Result: Suppressed CD14 mRNA and reduced cell-associated CD14 protein expression. Inhibited CD14 and NF-κB induction. Induced iκB and SOCS2 expression and STAT3 phosphorylation. |
| In Vivo | 2'-Fucosyllactose (2'-FL; 100 mg (200 μL); i.g.; daily, for 4 d; C57BL/6 mice with AIEC infection) inhibits AIEC infection and inflammation in vivo[1]. Animal Model: C57BL/6 mice (8 weeks) with AIEC (uropathogenic E. coli, and adherent-invasive E. coli) infection[1] Dosage: 100 mg (200 μL) Administration: Oral gavage; daily, for 4 days Result: Had colons lengths were closer to normal. Inhibited the colonisation of the colonic mucosa by O83-positive bacteria. Decreased CD14 expression, CD14 mRNA levels, IL-6, IL-17 and TNF-α levels in colonic. |
| References |
| Density | 1.68g/cm3 |
|---|---|
| Boiling Point | 902.2ºC at 760 mmHg |
| Melting Point | 230-231 °C |
| Molecular Formula | C18H32O15 |
| Molecular Weight | 488.43800 |
| Flash Point | 311.9ºC |
| Exact Mass | 488.17400 |
| PSA | 248.45000 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.631 |