41263-94-9

• 常用中文名：2'-岩藻糖基乳糖
• 常用英文名：2'-Fucosyllactose
• CAS号：41263-94-9
• 分子式：C₁₈H₃₂O₁₅
• 分子量：488.43800
• 相关类别： 信号通路 免疫及炎症 白细胞介素相关
• 发布时间：2017-01-08 14:00:44
• 更新时间：2026-07-02 07:39:31
• 2'-岩藻糖基乳糖(2'-FL)是一种可以从母乳中提取的低聚糖。2'-岩藻糖基乳糖调节CD14的表达,缓解结肠炎并调节肠道微生物。2'-岩藻糖基乳糖刺激T细胞增加IFN-γ的生成,并降低IL-6、IL-17和TNF-α的细胞因子生成[1][2]。

名称

• 中文名: 2'-岩藻糖基乳糖
• 英文名: 2′-Fucosyl-D-lactose
• 中文别名: 2'-岩藻基乳糖; 岩藻基乳糖; 2'-岩藻糖基乳糖 2'FUCOSYLLACTOSE 1KG大包装; 2'-岩藻糖基乳糖 - 合成的; 2'-岩藻糖基乳糖检测标准品; 2'-岩藻糖基乳糖,10 MM DMSO 溶液; 2'-岩藻糖基乳糖标准品; 2'-岩藻糖基乳糖(); (2R,3R,4R,5R)-4-(((2S,3R,4S,5R,6R)-4,5-二羟基-6-(羟甲基)-3-(((2S,3S,4R,5S,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)-2,3,5,6-四羟基己醛; 2'-岩藻糖基乳糖 -MIN; 2'-岩藻糖基乳糖/2-FL
• 英文别名: 2-FUCOSYL-D-LACTOSE; 2'-Fucosyllactose - Synthetic; Deoxy-5-propgyloxyuridine; Terthiophene-5-cboxaldehyde; Nitrophenyl-b-D-xylopyranoside ≥ Deoxy-2-fluoroadenosine; H)-yl)methyl)-4-fluorobenzonitrile; biphenyl]-4-yl]methyl]-cyclopentanecboxamide; Deoxy-2-O-ethyluridine; 13C5]Uridine; Methoxybiphenyl-4-boronic acid pinacol ester; Deoxy-6-thio Guanosine; 2'-FUCOSYLLACTOSE FROM HUMAN MILK; diphosphate trisodium salt hydrate; Methyl-adenosine-(Bz)-succinyl-G; ALPHA-L-FUC-[1-]-BETA-D-GAL-[1-]-D-GLC; 5R)-4-[(2S; (2R,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanal; O-monothiophosphate; 6R)-4; Isopropylacetanilide; Deoxy-5-azacytidine (HPLC); alpha-L-Fu-(1-)-beta-D-Galp-(1-)-D-GlNAc; fluoroinosine; α-l-fuc-(1→2)-β-d-gal-(1→4)-d-glc; FUC-ALPHA1-2GAL-BETAGLC; 2'FL-BSA; Deoxy-5-iodouridine; O-6-deoxy-alpha-L-galactopyranosyl-O-beta-D-galactopyranosyl- (2R; i docetaxel; N-[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]-L-γ Methoxy-biphenyl-4-cbaldehyde; D]imidazole, Hydrochloride Hydrate (Glu-P-1); O-DMT-guanosine-(DMF)-succinyl G 1000Å; 2'-Fucosyllactose - min; D-abinofuranosyluracil; Deoxy-N-(2-methyl-1-oxopropyl)-guanosine; Fluoro-5-methyl-1-β Hydroxy-3-phenylpropiophenone; 41-9 2-Fucosyllactose 2'FL AC1L55O8 HMDB02098 D-Glucose; O-DMT-N4-isobutyrylcytidine; 5-dihydroxy-6-(hydroxymethyl)-3-[(2S; difluorocytidine; C-Methylinosine; 2'Fucosyllactose (2'FL); (Fmoc-aminomethyl)biphenyl-2-cboxylic acid (HPLC); Cyanobiphenyl-3-cboxylic acid; glutamyl-L-cysteinylglycine Bimol. (2&rr; Deoxy-5-iodocytidine; (2R,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-oxan-2-yl]oxy-2,3,5,6-tetrahydroxy-hexanal; Acetoxycocaine Hydrochloride; Deoxy-N6-methyladenosine; 4-Bis(aminophenyl)methane; fluoroadenosine-triphosphate tetralithium salt; kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-cboxylicacid,5,16-bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-,methyl ester, (9S,10R,12R); [(a,b)-methyleno]triphosphate sodium salt; Deoxy-N2-isobutyrylcytidine

物化性质

• 密度: 1.68g/cm3
• 沸点: 902.2ºC at 760 mmHg
• 熔点: 230-231 °C
• 分子式: C₁₈H₃₂O₁₅
• 分子量: 488.43800
• 闪点: 311.9ºC
• 精确质量: 488.17400
• PSA: 248.45000
• 外观性状: 固体
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.631
• 储存条件: -20°C，密封，惰性气体

生物活性

• 描述: 2'-岩藻糖基乳糖(2'-FL)是一种可以从母乳中提取的低聚糖。2'-岩藻糖基乳糖调节CD14的表达,缓解结肠炎并调节肠道微生物。2'-岩藻糖基乳糖刺激T细胞增加IFN-γ的生成,并降低IL-6、IL-17和TNF-α的细胞因子生成[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 靶点:

  Target: IFN-γ, IL-6, IL-17, and TNF-α[1]

• 体外研究: 2'-岩藻糖基乳糖(2'-FL；0-12 mg/mL；48 h)抑制T84细胞中细胞相关CD14表达,并减弱LPS(100μg/mL)刺激的IL-8分泌[1]。2'-岩藻糖基乳糖(2 mg/mL；48 h；T84和HCT8细胞)可改善细菌入侵引起的炎症。2'-岩藻糖基乳糖抑制ETEC侵袭并减弱随后的IL-8分泌[1]。2'-岩藻糖基乳糖(2 mg/mL；48 h；T84和HCT8细胞)诱导巨噬细胞移动抑制因子信号通路,抑制炎症[1]。Western Blot分析[1]细胞系：T84细胞浓度：0、2和4 mg/mL培养时间：48小时结果：抑制CD14 mRNA并降低细胞相关CD14蛋白表达。Western Blot分析[1]细胞系：T84和HCT8细胞T84和HCT8细胞浓度：2 mg/mL培养时间：48小时结果：抑制CD14 mRNA并降低细胞相关CD14蛋白表达。抑制CD14和NF-κB的诱导。诱导iκB和SOCS2表达和STAT3磷酸化。
• 体内研究: 2'-岩藻糖基乳糖(2'-FL；100 mg(200μL)；i、 例如。；每日,连续4d；感染AIEC的C57BL/6小鼠)抑制体内AIEC感染和炎症[1]。动物模型：AIEC感染C57BL/6小鼠(8周)[1]剂量：100 mg(200μL)口服；结果：结肠长度接近正常值。抑制O83阳性细菌对结肠粘膜的定植。结肠中CD14表达、CD14 mRNA水平、IL-6、IL-17和TNF-α水平降低。
• 参考文献:

  [1]. He Y, et, al. The human milk oligosaccharide 2'-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation. Gut. 2016 Jan;65(1):33-46.

  [2]. Eiwegger T, et, al. Human milk--derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Pediatr Res. 2004 Oct;56(4):536-40.

安全

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport