76166-59-1
76166-59-1 structure
- Name: Derrone
- Chemical Name: Derrone
- CAS Number: 76166-59-1
- Molecular Formula: C20H16O5
- Molecular Weight: 336.34
- Catalog: Natural product Flavonoids
- Create Date: 2017-09-26 18:26:51
- Modify Date: 2025-08-25 11:24:00
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Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2].
| Name | Derrone |
|---|---|
| Synonyms |
5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one
4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl- |
| Description | Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6 μM (Aurora kinase B), 22.3 μM (Aurora kinase A)[1] |
| In Vitro | Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60 μM Derrone, respectively[1]. Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62)[2]. Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 584.1±50.0 °C at 760 mmHg |
| Molecular Formula | C20H16O5 |
| Molecular Weight | 336.34 |
| Flash Point | 214.6±23.6 °C |
| Exact Mass | 336.099762 |
| PSA | 79.90000 |
| LogP | 5.53 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.660 |
| Hazard Codes | Xi |
|---|