ALLM

Modify Date: 2024-01-03 20:43:37

ALLM Structure
ALLM structure
 Common Name ALLM
CAS Number 110115-07-6 Molecular Weight 401.564
Density 1.1±0.1 g/cm3 Boiling Point 676.5±55.0 °C at 760 mmHg
Molecular Formula C19H35N3O4S Melting Point N/A
MSDS Chinese Flash Point 362.9±31.5 °C

 Use of ALLM


ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].

 Names

Name calpain inhibitor ii
Synonym More Synonyms

 ALLM Biological Activity

Description ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].
Related Catalog
In Vivo ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2]. ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2]. Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2] Dosage: 0.05, 0.5, and 2.5 mg/kg Administration: Intraperitoneally; every 24 h for 1 week Result: Showed significantly better motor function.
References

[1]. Stangl V, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 2004 Feb;18(2):272-9.

[2]. Arataki S, et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma. 2005 Mar;22(3):398-406.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 676.5±55.0 °C at 760 mmHg
Molecular Formula C19H35N3O4S
Molecular Weight 401.564
Flash Point 362.9±31.5 °C
Exact Mass 401.234833
PSA 129.67000
LogP 2.64
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.496
Storage condition −20°C
Water Solubility Very slightly soluble (0.52 g/L) (25 ºC)

 Safety Information

Hazard Codes Xi
Safety Phrases S22-S24/25
WGK Germany 3

 Synonyms

N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxo-2-butanyl]-L-leucinamide
N-AC-LEU-LEU-METHIONINAL
AC-LEU-LEU-L-METHIONINAL
L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-
Ac-Leu-Leu-Met-al
N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxobutan-2-yl]-L-leucinamide
ALLM
AC-LEU-LEU-MET-ALDEHYDE
AC-LEU-LEU-METHIONINAL
AC-LEU-LEU-MET-CHO
N-ACETYL-LEU-LEU-MET-CHO
MFCD00065506
AC-LLM-CHO
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Chemsrc provides ALLM(CAS#:110115-07-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ALLM are included as well.>> amp version: ALLM

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