ALLM

Modify Date: 2024-01-03 20:43:37

ALLM structure	Common Name	ALLM
	CAS Number	110115-07-6	Molecular Weight	401.564
	Density	1.1±0.1 g/cm3	Boiling Point	676.5±55.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₃₅N₃O₄S	Melting Point	N/A
	MSDS	Chinese	Flash Point	362.9±31.5 °C

Use of ALLM

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].

Name	calpain inhibitor ii
Synonym	More Synonyms

Description	ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
In Vivo	ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2]. ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2]. Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2] Dosage: 0.05, 0.5, and 2.5 mg/kg Administration: Intraperitoneally; every 24 h for 1 week Result: Showed significantly better motor function.
References	[1]. Stangl V, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 2004 Feb;18(2):272-9. [2]. Arataki S, et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma. 2005 Mar;22(3):398-406.

Density	1.1±0.1 g/cm3
Boiling Point	676.5±55.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₅N₃O₄S
Molecular Weight	401.564
Flash Point	362.9±31.5 °C
Exact Mass	401.234833
PSA	129.67000
LogP	2.64
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.496
Storage condition	−20°C
Water Solubility	Very slightly soluble (0.52 g/L) (25 ºC)

Hazard Codes	Xi
Safety Phrases	S22-S24/25
WGK Germany	3

N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxo-2-butanyl]-L-leucinamide

N-AC-LEU-LEU-METHIONINAL

AC-LEU-LEU-L-METHIONINAL

L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-

Ac-Leu-Leu-Met-al

N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxobutan-2-yl]-L-leucinamide

ALLM

AC-LEU-LEU-MET-ALDEHYDE

AC-LEU-LEU-METHIONINAL

AC-LEU-LEU-MET-CHO

N-ACETYL-LEU-LEU-MET-CHO

MFCD00065506

AC-LLM-CHO

GL Biochem (Shanghai) Ltd.
China
Product Name: Calpain Inhibitor II
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Calpain inhibitor ii
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Calpain Inhibitor II
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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