DC Chemicals Limited
China
Product Name: ICI 89406
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

53671-71-9

53671-71-9 structure

53671-71-9 structure

Name: ICI 89406
Chemical Name: 1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea
CAS Number: 53671-71-9
Molecular Formula: C₁₉H₂₂N₄O₃
Molecular Weight: 354.40300
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2017-05-19 11:27:23
Modify Date: 2024-01-12 11:10:51
ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET[1][2].

Name	1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea
Synonyms	Ici 89 406

Description	ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
In Vivo	Animal Model: Rats[2]. Dosage: 0.6, 5 or 50 mg/kg. Administration: Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis). Result: Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.
References	[1]. Marilyn P Law, et al. Are [O-methyl-11C]derivatives of ICI 89,406 beta1-adrenoceptor selective radioligands suitable for PET? Eur J Nucl Med Mol Imaging. 2008 Jan;35(1):174-85. [2]. B Costall, et al. Changes in dopamine receptor status after denervation or chronic receptor stimulation [proceedings]. Br J Pharmacol. 1979 Jul;66(3):492P-493P.

Density	1.25 g/cm3
Boiling Point	575ºC at 760 mmHg
Melting Point	155-156 °C
Molecular Formula	C₁₉H₂₂N₄O₃
Molecular Weight	354.40300
Flash Point	301.5ºC
Exact Mass	354.16900
PSA	106.41000
LogP	2.56408
Index of Refraction	1.613
Storage condition	2-8°C

HS Code	2926909090

85850-48-2 structure

85850-48-2

38465-16-6 structure

38465-16-6

~40%

53671-71-9 structure

53671-71-9

Literature: Kopka, Klaus; Wagner, Stefan; Riemann, Burkhard; Law, Marilyn P; Puke, Carsten; Luthra, Sajinder K; Pike, Victor W; Wichter, Thomas; Schmitz, Wilhelm; Schober, Otmar; Schaefers, Michael Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3513 - 3527

53673-01-1 structure

53673-01-1

38465-16-6 structure

38465-16-6

~10%

53671-71-9 structure

53671-71-9

Literature: Large, M.S.; Smith, L.H. Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1286 - 1292

611-20-1 structure

611-20-1

~%

53671-71-9 structure

53671-71-9

Literature: Kopka, Klaus; Wagner, Stefan; Riemann, Burkhard; Law, Marilyn P; Puke, Carsten; Luthra, Sajinder K; Pike, Victor W; Wichter, Thomas; Schmitz, Wilhelm; Schober, Otmar; Schaefers, Michael Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3513 - 3527

215654-49-2 structure

215654-49-2

~%

53671-71-9 structure

53671-71-9

Literature: Kopka, Klaus; Wagner, Stefan; Riemann, Burkhard; Law, Marilyn P; Puke, Carsten; Luthra, Sajinder K; Pike, Victor W; Wichter, Thomas; Schmitz, Wilhelm; Schober, Otmar; Schaefers, Michael Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3513 - 3527

Precursor 4
38465-16-6 53673-01-1 611-20-1 215654-49-2
DownStream 0

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%