Triethylene glycol bis(p-toluenesulfonate)

Modify Date: 2025-08-20 09:13:41

Triethylene glycol bis(p-toluenesulfonate) Structure
Triethylene glycol bis(p-toluenesulfonate) structure
 Common Name Triethylene glycol bis(p-toluenesulfonate)
CAS Number 19249-03-7 Molecular Weight 458.546
Density 1.3±0.1 g/cm3 Boiling Point 608.4±55.0 °C at 760 mmHg
Molecular Formula C20H26O8S2 Melting Point 78-82 °C(lit.)
MSDS Chinese USA Flash Point 321.7±31.5 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Triethylene glycol bis(p-toluenesulfonate)


Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
Synonym More Synonyms

  Biological Activity

Description Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 608.4±55.0 °C at 760 mmHg
Melting Point 78-82 °C(lit.)
Molecular Formula C20H26O8S2
Molecular Weight 458.546
Flash Point 321.7±31.5 °C
Exact Mass 458.106903
PSA 121.96000
LogP 2.34
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.545

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2909309090

 Customs

HS Code 2909309090
Summary 2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles1

More Articles
G.W. Gokel, S.H. Korzeniowski

Macrocyclic Polyether Synthesis , (1982)

 Synonyms

Ethanol, 2,2'-(1,2-ethanediylbis(oxy))bis-, bis(4-methylbenzenesulfonate)
1,2-Ethanediylbis(oxy-2,1-ethanediyl) bis(4-methylbenzenesulfonate)
2-[2-(2-([(4-Methylphenyl)sulfonyl]oxy)ethoxy)ethoxy]ethyl 4-methylbenzenesulfonate
TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE
ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(4-methylbenzenesulfonate)
Triethylene Glycol Bis(p-toluenesulfonate)
TsOCH2(CH2OCH2)2CH2OTs
Triethylene glycol di(p-toluenesulfonate)
Triethylene Glycol Di-p-tosylate
triethylene glycol bis(4-toluenesulfonate)
1,2-Bis(2-tosyloxyethoxy)ethane
Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate)
bis-tosylated triethyleneglycol
MFCD00048096
Triethylene glycol ditosylate
1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane
2,2'-(Ethylenedioxy)diethyl Ditosylate
(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
2-(2-{2-[(4-methylphenyl)sulfonyloxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfon ate
Tos-PEG4-Tos
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Chemsrc provides CAS#:19249-03-7 MSDS, density, melting point, boiling point, structure, etc. Its name is Triethylene glycol bis(p-toluenesulfonate)>> amp version: Triethylene glycol bis(p-toluenesulfonate)

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