204395-49-3

204395-49-3 structure

204395-49-3 structure

Name: Buspirone-d8
Chemical Name: 8-[1,1,2,2,3,3,4,4-octadeuterio-4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione,hydrochloride
CAS Number: 204395-49-3
Molecular Formula: C₂₁H₂₃D₈N₅O₂
Molecular Weight: 393.55
Create Date: 2018-05-28 08:00:00
Modify Date: 2024-01-09 11:46:54
Buspirone-d8 is deuterium labeled Buspirone.

Name	8-[1,1,2,2,3,3,4,4-octadeuterio-4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione,hydrochloride
Synonyms	8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl-1,1,2,2,3,3,4,4-d]- Buspirone-d8 Hydrochloride 8-{4-[4-(2-Pyrimidinyl)-1-piperazinyl](H)butyl}-8-azaspiro[4.5]decane-7,9-dione 8-{4-[4-(Pyrimidin-2-yl)piperazin-1-yl](H)butyl}-8-azaspiro[4.5]decane-7,9-dione

Description	Buspirone-d8 is deuterium labeled Buspirone.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Density	1.2±0.1 g/cm3
Boiling Point	613.9±65.0 °C at 760 mmHg
Melting Point	198-200ºC
Molecular Formula	C₂₁H₂₃D₈N₅O₂
Molecular Weight	393.55
Flash Point	325.1±34.3 °C
Exact Mass	393.298004
PSA	69.64000
LogP	3.43
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.604

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution