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4097-22-7

4097-22-7 structure

4097-22-7 structure

Name: 2',3'-Dideoxyadenosine
Chemical Name: 2',3'-Dideoxyadenosine
CAS Number: 4097-22-7
Molecular Formula: C₁₀H₁₃N₅O₂
Molecular Weight: 235.242
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-09-03 16:37:34
Modify Date: 2026-07-31 20:23:46
2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1].

Name	2',3'-Dideoxyadenosine
Synonyms	9-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-9H-purin-6-amine (2′,3′-dideoxyadenosine) DDA ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol Dideoxyadenosine, 10 mM in DMSO DIDEOXYADENOSINE ,DDA [(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methanol [(2S,5R)-5-(6-Aminopurin-9-yl)oxolan-2-yl]methanol 2,3-Dideoxyadenosine (ddA) extrapure ddA 9-(2,3-Dideoxy-beta-D-ribofuranosyl)adenine EINECS 223-853-2 Didanosine Impurity 7（Didanosine Impurity G） Didanosine Related Compound B (25 mg) (2',3'-dideoxyadenosine) Didanosine impurity G CRS 9-(2,3-Dideoxy-beta-D-glycero-pentofuranosyl)-9H-purin-6-amine (2',3'-Dideoxyadenosine) 9-(2,3-Dideoxy-β-D-ribofuranosyl)adenine MFCD00010534 Didanosine Related Compound B (2'',3''-dideoxyadenosine) Didanosine Related CoMpound B Dideoxyadenosine //BP DIDEOXYADENOSINE 2',3'-dideoxy adenosine DDA, antiviral drug, related substance B of ddI GL101975 9-(2,3,5-trideoxy-β-D-glycero-pentofuranosyl)-9H-purin-6-amine (2′,3′,5′-trideoxyadenosine) 2',3'-ddA 9-(2,3-Dideoxy-beta-D-glycero-pento 2',3'-DIDEOXYADENOSINE extapure Dideoxyadenosine Didanosine impurity G Adenosine, 2',3'-dideoxy 2', 3'-Dideoxyadenosine 6-Amino-9-(2',3'-dideoxy-b-D-glycero-pentofuranosyl)purine [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methanol Didanosine Related Compound B (2',3'-dideoxyadenosine) Didanosine Impurity G 2’,3’-dideoxy-adenosin 9-(2,3-Dideoxy-beta-D-ribofuranosyl)adenine BETA-D-2',3'-DIDEOXYADENOSINE Didanosin Imp G 2',3'-Dideoxy-D-adenosine 2',3'-Dideoxyadenosine> ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)Methanol [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydro-2-furanyl]methanol

Description	2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV[1]
In Vitro	2',3'-Dideoxyadenosine inhibits HIV-1 and simian immunodeficiency virus (SIV) in MT-4 cells with EC50s of 5.27 and 5.3 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in human T-lymphocyte CEM cells with EC50s of 4 μM and 8 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in Molt 4/C8 cells with EC50s of 4 μM and 5.5 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in C8166 cells with EC50s of 17 μM and 22 μM, respectively. 2',3'-Dideoxyadenosine inhibits murine sarcoma virus (MSV) in C3H/3T3 cells with an EC50 of 24 μM[1].
References	[1]. Balzarini J, et al. Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Lett. 1997 Jun 30;410(2-3):324-8.

Density	1.8±0.1 g/cm3
Boiling Point	539.1±60.0 °C at 760 mmHg
Melting Point	181-184 °C(lit.)
Molecular Formula	C₁₀H₁₃N₅O₂
Molecular Weight	235.242
Flash Point	279.9±32.9 °C
Exact Mass	235.106918
PSA	99.08000
LogP	-0.43
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.822
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7358900

CHEMICAL NAME :: Adenosine, 2',3'-dideoxy-

CAS REGISTRY NUMBER :: 4097-22-7

BEILSTEIN REFERENCE NO. :: 0619924

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C10-H13-N5-O2

MOLECULAR WEIGHT :: 235.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19600 mg/kg/28D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg/3D (Continuous)

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 18,168,1991

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	C
Risk Phrases	R34
Safety Phrases	26-27-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	AU7358900
HS Code	2934999090

Precursor 7
7057-48-9 66224-66-6 5983-09-5 205189-73-7
58-61-7 32780-06-6 69530-93-4
DownStream 4
69655-05-6 4097-22-7 126502-08-7 121353-86-4

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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