2',3'-Dideoxyadenosine

Modify Date: 2024-01-02 12:03:28

2',3'-Dideoxyadenosine structure	Common Name	2',3'-Dideoxyadenosine
	CAS Number	4097-22-7	Molecular Weight	235.242
	Density	1.8±0.1 g/cm3	Boiling Point	539.1±60.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₃N₅O₂	Melting Point	181-184 °C(lit.)
	MSDS	Chinese USA	Flash Point	279.9±32.9 °C

Use of 2',3'-Dideoxyadenosine

2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1].

Name	2',3'-Dideoxyadenosine
Synonym	More Synonyms

Description	2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV[1]
In Vitro	2',3'-Dideoxyadenosine inhibits HIV-1 and simian immunodeficiency virus (SIV) in MT-4 cells with EC50s of 5.27 and 5.3 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in human T-lymphocyte CEM cells with EC50s of 4 μM and 8 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in Molt 4/C8 cells with EC50s of 4 μM and 5.5 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in C8166 cells with EC50s of 17 μM and 22 μM, respectively. 2',3'-Dideoxyadenosine inhibits murine sarcoma virus (MSV) in C3H/3T3 cells with an EC50 of 24 μM[1].
References	[1]. Balzarini J, et al. Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Lett. 1997 Jun 30;410(2-3):324-8.

Density	1.8±0.1 g/cm3
Boiling Point	539.1±60.0 °C at 760 mmHg
Melting Point	181-184 °C(lit.)
Molecular Formula	C₁₀H₁₃N₅O₂
Molecular Weight	235.242
Flash Point	279.9±32.9 °C
Exact Mass	235.106918
PSA	99.08000
LogP	-0.43
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.822
Storage condition	2-8°C

2',3'-Dideoxyadenosine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7358900

CHEMICAL NAME :: Adenosine, 2',3'-dideoxy-

CAS REGISTRY NUMBER :: 4097-22-7

BEILSTEIN REFERENCE NO. :: 0619924

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C10-H13-N5-O2

MOLECULAR WEIGHT :: 235.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19600 mg/kg/28D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg/3D (Continuous)

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 18,168,1991

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	C
Risk Phrases	R34
Safety Phrases	26-27-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	AU7358900
HS Code	2934999090

Precursor 7
CAS#:7057-48-9 beta-L-D4A CAS#:66224-66-6 6H-Purin-6-imin... CAS#:5983-09-5 2',3'-Dideoxyuridine CAS#:205189-73-7 (2R,3R,4R,5R)-2...
CAS#:58-61-7 Adenosine CAS#:32780-06-6 (5S)-5-(Hydroxy... CAS#:69530-93-4 5'-O-[(1,1-dime...
DownStream 4
CAS#:69655-05-6 2',3'-Dideoxyinosine CAS#:4097-22-7 2',3'-Dideoxyad... CAS#:126502-08-7 [(2S,5R)-5-puri... CAS#:121353-86-4 [(2S,5R)-5-(6-a...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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DDA

((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol

[(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methanol

Dideoxyadenosine

Didanosine impurity G

6-Amino-9-(2',3'-dideoxy-b-D-glycero-pentofuranosyl)purine

EINECS 223-853-2

[(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methanol

2-furanmethanol, 5-(6-amino-9H-purin-9-yl)tetrahydro-, (2S,5R)-

2',3'-Dideoxyadenosine

9-(2,3-Dideoxy-β-D-ribofuranosyl)adenine

MFCD00010534

9-(2,3-Dideoxy-beta-D-ribofuranosyl)adenine

[(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydro-2-furanyl]methanol

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China
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China
Product Name: Cytidine-5'-triphosphoric acid
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2',3'-Dideoxyadenosine

Use of 2',3'-Dideoxyadenosine

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