6894-43-5
6894-43-5 structure
- Name: Kahweol
- Chemical Name: kahweol
- CAS Number: 6894-43-5
- Molecular Formula: C20H26O3
- Molecular Weight: 314.419
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-06-24 17:53:07
- Modify Date: 2024-01-08 18:41:48
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Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.
| Name | kahweol |
|---|---|
| Synonyms | (1S,4S,12S,13R,16R,17R)-17-(Hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.0.0.0]nonadeca-5(9),6,10-trien-17-ol |
| Description | Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. |
|---|---|
| Related Catalog | |
| Target |
AMPK; adipogenesis; apoptosis[1] |
| In Vitro | Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells[1]. Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells[1]. Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only[1]. kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells[2]. kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism[2]. Western Blot Analysis[2] Cell Line: 3T3-L1 cells Concentration: 0, 5, 10, 25 μg/ml Incubation Time: Result: Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 476.6±45.0 °C at 760 mmHg |
| Melting Point | 88-90 °C |
| Molecular Formula | C20H26O3 |
| Molecular Weight | 314.419 |
| Flash Point | 242.0±28.7 °C |
| Exact Mass | 314.188202 |
| PSA | 53.60000 |
| LogP | 3.38 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.623 |
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~97%
6894-43-5 |
| Literature: Corey, E. J.; Xiang, Yi Bin Tetrahedron Letters, 1987 , vol. 28, # 45 p. 5403 - 5406 |
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6894-43-5 |
| Literature: Tetrahedron Letters, , vol. 28, # 45 p. 5403 - 5406 |
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6894-43-5 |
| Literature: Tetrahedron Letters, , vol. 28, # 45 p. 5403 - 5406 |
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6894-43-5 |
| Literature: Tetrahedron Letters, , vol. 28, # 45 p. 5403 - 5406 |
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6894-43-5 |
| Literature: Tetrahedron Letters, , vol. 28, # 45 p. 5403 - 5406 |
