278603-08-0

278603-08-0 structure

Name: NH 125
Chemical Name: 1-benzyl-3-hexadecyl-2-methylimidazol-1-ium,iodide
CAS Number: 278603-08-0
Molecular Formula: C₂₇H₄₅IN₂
Molecular Weight: 524.564
Catalog: Biochemical Inhibitor Neuronal Signaling CaMK inhibitor
Create Date: 2017-04-03 14:03:23
Modify Date: 2025-08-25 18:14:29
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also could induce eEF2 phosphorylation, with an IC50 of 60 nM for eEF-2K.

Name	1-benzyl-3-hexadecyl-2-methylimidazol-1-ium,iodide
Synonyms	1-Benzyl-3-cetyl-2-methylimidazolium iodide NH125 1H-Imidazolium, 1-hexadecyl-2-methyl-3-(phenylmethyl)-, iodide (1:1) eEF-2 Kinase Inhibitor,NH125 HMS3229F01 3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide

Description	NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also could induce eEF2 phosphorylation, with an IC50 of 60 nM for eEF-2K.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Cancer
Target	eEF-2K:60 nM (IC50)
In Vitro	NH125 inhibits eEF-2 kinase activity (IC50 = 60 nM) in vitro, blocks the phosphorylation of eEF-2 in intact cells, and shows relative selectivity over other protein kinases: protein kinase C (IC50 = 7.5 μM), protein kinase A (IC50 = 80 μM), and calmodulin-dependent kinase II (IC50 > 100 μM). NH125 decreases the viability of 10 cancer cell lines with IC50s ranging from 0.7 to 4.7 μM. Forced overexpression of eEF-2 kinase in a glioma cell line produces 10-fold resistance to NH125. In conclusion, these results suggest that identification of potent inhibitors of eEF-2 kinase may lead to the development of new types of anticancer drugs[1]. Anticancer effect of NH125 is not mediated through inhibition of eEF2K. Inhibition of cell growth correlates with induction of peEF2[2].
References	[1]. Arora S, et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 2003 Oct 15;63(20):6894-9. [2]. Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286(51):43951-8.

Melting Point	88.2-94.9ºC
Molecular Formula	C₂₇H₄₅IN₂
Molecular Weight	524.564
Exact Mass	524.262756
PSA	8.81000
LogP	4.61760
Appearance	solid \| white to off-white
Storage condition	−20°C
Water Solubility	DMSO: 20 mg/mL

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

278603-08-0	2100306-83-8
2055024-51-4	63721-14-2
2055041-59-1	60711-71-9
54384-47-3	1964503-36-3
63721-06-2	2171072-53-8
1256784-63-0	1256560-94-7
1358754-12-7	1389064-43-0
186046-04-8	1175526-34-7
2231404-52-5	1301214-67-4
2824986-73-2	76906-80-4