CL-82198

Modify Date: 2024-01-08 22:12:27

CL-82198 Structure
CL-82198 structure
Common Name CL-82198
CAS Number 307002-71-7 Molecular Weight 302.37
Density N/A Boiling Point 537.1ºC at 760 mmHg
Molecular Formula C17H22N2O3 Melting Point N/A
MSDS Chinese USA Flash Point 278.6ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of CL-82198


CL-82198 is a selective inhibitor of MMP-13.In vitro: In the presence of 10 and 20 μM of the specific MMP-13 inhibitor, CL-82198, migration of the LS174 cells was significantly reduced by 55 and 52%, respectively. . CL-82198 binds to the S1' pocket of MMP-13 leading to 89% enzyme inhibition at a concentration of 10 μg/ml. The addition of the specific MMP-13 inhibitor CL-82198 at a concentration of 10 μM resulted in a 45±5.6% reduction in the migration of LS174 cells.

 Names

Name N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride
Synonym More Synonyms

 CL-82198 Biological Activity

Description CL-82198 is a selective inhibitor of MMP-13.In vitro: In the presence of 10 and 20 μM of the specific MMP-13 inhibitor, CL-82198, migration of the LS174 cells was significantly reduced by 55 and 52%, respectively. . CL-82198 binds to the S1' pocket of MMP-13 leading to 89% enzyme inhibition at a concentration of 10 μg/ml. The addition of the specific MMP-13 inhibitor CL-82198 at a concentration of 10 μM resulted in a 45±5.6% reduction in the migration of LS174 cells.
Related Catalog
References

[1]. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488.

[2]. Wohlauer M et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53.

 Chemical & Physical Properties

Boiling Point 537.1ºC at 760 mmHg
Molecular Formula C17H22N2O3
Molecular Weight 302.37
Flash Point 278.6ºC
PSA 54.71000
LogP 3.40580
Storage condition 2-8℃

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

IN1376
N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide
CL-82198
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