51938-32-0

51938-32-0 structure

Name: Schaftoside
Chemical Name: schaftoside
CAS Number: 51938-32-0
Molecular Formula: C₂₆H₂₈O₁₄
Molecular Weight: 564.49
Catalog: Biochemical Plant extracts
Create Date: 2018-08-31 17:04:29
Modify Date: 2026-07-06 19:27:54
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1].

Name	schaftoside
Synonyms	Shaftoside Apigenin 8-C-\|A-L-arabinoside 6-C-\|A-D-glucoside Mitochondrial Metabolism,Inhibitor,Dynamin,Schaftoside,Toll-like Rector (T,Autophagy,inhibit,MyD88 4H-1-Benzopyran-4-one, 8-α-L-abinopyranosyl-6-β-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl) Schaftoside from Desmodium styracifolium (Osbeck) Merr 6-C-beta-D-Glucosyl-8-C-alpha-L-abinosylapigenin 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-8-((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)-4H-chromen-4-one 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2ytetrahydH-chromen-4-one (non-preferred name) schaftozide 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-8-[(2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]-4H-chromen-4-one (non-preferred name) Schaftoside-RM Schaftos 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5 Apigenin 8-C-α-L-abinoside 6-C-β-D-glucoside Schaftoside, 10 mM in DMSO 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one 8-(α-L-abinopyranosyl)-6-(β-D-glucopyranosyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Trifotene Impurity 7 8-(D-Arabinopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl D-glucopyranoside 4',5,7-Trihydroxy-6-(β-D-glucopyranosyl)-8-(α-L-abinopyranosyl)flavone

Description	Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Signaling Pathways >> Immunology/Inflammation >> MyD88 Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism Signaling Pathways >> Cytoskeleton >> Dynamin
In Vitro	Schaftoside inhibits three pro-inflammatory enzymatic activities: secretory phospholipase A2 (sPLA2), lipoxygenase (LOX), and cyclooxygenase 2 (COX-2). Schaftoside also inhibits mRNA and protein expressions of proinflammatory cytokines(IL-1β, TNF-α, and IL-6)[1].
References	[1]. Zhou K, et al. Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells. J Pharmacol Sci. 2019 Jan;139(1):15-22.

Density	1.8±0.1 g/cm3
Boiling Point	1028.2±65.0 °C at 760 mmHg
Melting Point	228ºC
Molecular Formula	C₂₆H₂₈O₁₄
Molecular Weight	564.49
Flash Point	342.7±27.8 °C
Exact Mass	596.137756
PSA	269.43000
LogP	-3.06
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.754
Storage condition	2-8°C

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
RTECS	DJ2977250
HS Code	29389090

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