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2415-24-9

2415-24-9 structure
2415-24-9 structure
  • Name: Catalpol
  • Chemical Name: Catalpol
  • CAS Number: 2415-24-9
  • Molecular Formula: C15H22O10
  • Molecular Weight: 362.329
  • Catalog: Natural product Iridoid derivative
  • Create Date: 2018-08-29 14:15:34
  • Modify Date: 2025-08-20 05:13:05
  • Catalpol, an iridoid glycoside, has neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.IC50 Value:Target: neuroprotective, anti-inflammatory, and anti-hepatitis virus natural product.In vitro: Catalpol could be encapsulated into composite nanofibers and induce differentiation of hASCs into neural-like cells, which might offer new avenues in nerve regeneration [1].In vivo: The pharmacokinetics of catalpol in normal and doxorubicin-induced chronic kidney disease rats after oral administration of Rehmannia glutinosa extract was determined, and the extraction recoverie of catalpol was higher than 68.24% [2]. The protective effect of catalpol on renal IRI mice through suppressing phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt)-endothelial nitric oxide synthase (eNOS) and against inflammation, and the possible underlying mechanism [3].
Name Catalpol
Synonyms EINECS 219-324-0
catalpinoside
des-p-hydroxybenzoyl-catalposid
CATAPOL
6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl hexopyranoside
Hexopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl
catalposide
methyl iridoid glycoside
Description Catalpol, an iridoid glycoside, has neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.IC50 Value:Target: neuroprotective, anti-inflammatory, and anti-hepatitis virus natural product.In vitro: Catalpol could be encapsulated into composite nanofibers and induce differentiation of hASCs into neural-like cells, which might offer new avenues in nerve regeneration [1].In vivo: The pharmacokinetics of catalpol in normal and doxorubicin-induced chronic kidney disease rats after oral administration of Rehmannia glutinosa extract was determined, and the extraction recoverie of catalpol was higher than 68.24% [2]. The protective effect of catalpol on renal IRI mice through suppressing phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt)-endothelial nitric oxide synthase (eNOS) and against inflammation, and the possible underlying mechanism [3].
Related Catalog
References

[1]. Zhao M, et al.Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract. Biomed Chromatogr. 2015 May 29.

[2]. Guo JH, et al.Potential Neurogenesis of Human Adipose-Derived Stem Cells on Electrospun Catalpol-Loaded Composite Nanofibrous Scaffolds. Ann Biomed Eng. 2015 Mar 31.

[3]. Zhu J,Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt-eNOS signaling and inflammation. Int J Clin Exp Med. 2015 Feb 15;8(2):2038-44.

[4]. Xu Z, et al.Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose-induced hepatic mitochondrial dysfunction. Acta Biochim Biophys Sin (Shanghai). 2015 Jul 2.
Density 1.7±0.1 g/cm3
Boiling Point 675.6±55.0 °C at 760 mmHg
Melting Point 203-205ºC
Molecular Formula C15H22O10
Molecular Weight 362.329
Flash Point 362.4±31.5 °C
Exact Mass 362.121307
PSA 161.60000
LogP -4.15
Vapour Pressure 0.0±4.7 mmHg at 25°C
Index of Refraction 1.679
Storage condition ?20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LZ5776816
CHEMICAL NAME :
beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy- 1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran- 2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a- beta,6-beta,6a-alpha))-
CAS REGISTRY NUMBER :
2415-24-9
LAST UPDATED :
199806
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H22-O10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,93,1968
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,93,1968
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
RTECS LZ5776816
81720-06-1 structure

81720-06-1

~%

2415-24-9 structure

2415-24-9

Literature: Oshio,H.; Inouye,H. Phytochemistry (Elsevier), 1982 , vol. 21, p. 133
6910-20-9 structure

6910-20-9

~%

81892-75-3 structure

81892-75-3

2415-24-9 structure

2415-24-9

Literature: Phytochemistry (Elsevier), , vol. 21, p. 231
75598-56-0 structure

75598-56-0

~%

121-34-6 structure

121-34-6

2415-24-9 structure

2415-24-9

Literature: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 43, # 5 p. 1023 - 1025
1374308-81-2 structure

1374308-81-2

~%

93-07-2 structure

93-07-2

2415-24-9 structure

2415-24-9

Literature: Helvetica Chimica Acta, , vol. 95, # 4 p. 586 - 593
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