Top Suppliers:I want be here
Related CAS#:
93-07-2 91-52-1
1521-38-6 42923-56-8
1162658-12-9 20624-87-7
1916-08-1 519-05-1
40163-56-2 2150-38-1
2229639-05-6 2228477-05-0
2137766-04-0 2228306-02-1
2228634-99-7 2138290-33-0
2229664-54-2 2228521-09-1
2731013-86-6 2228849-32-7

93-07-2

93-07-2 structure
93-07-2 structure
  • Name: Veratric acid
  • Chemical Name: 3,4-dimethoxybenzoic acid
  • CAS Number: 93-07-2
  • Molecular Formula: C9H10O4
  • Molecular Weight: 182.173
  • Catalog: Chemical reagent Organic reagent Aromatic acid
  • Create Date: 2018-09-17 22:13:13
  • Modify Date: 2025-08-20 17:58:09
  • Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
Name 3,4-dimethoxybenzoic acid
Synonyms MFCD00002500
EINECS 202-215-7
Benzoic acid, 3,4-dimethoxy-
3,4-Dimethoxybenzoic acid
Veratric acid
Description Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
Related Catalog
Target

COX-2[3]

In Vitro Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation and HDAC3 expression in RAW264.7 cells[1]. Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis[3]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
In Vivo Veratric acid (40 mg/kg, p.o., b.w.) significantly promotes ventricular function, reduces lipid peroxidation and increases antioxidants in l-NAME-induced hypertensive rats[2].
References

[1]. Choi WS, et al. Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. Int J Mol Med. 2015 Jan;35(1):202-10.

[2]. Saravanakumar M, et al. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. Br J Nutr. 2015 Nov 14;114(9):1385-94.

[3]. Shin SW, et al. Antagonist effects of veratric acid against UVB-induced cell damages. Molecules. 2013 May 10;18(5):5405-19.
Density 1.2±0.1 g/cm3
Boiling Point 302.9±22.0 °C at 760 mmHg
Melting Point 179-182 °C(lit.)
Molecular Formula C9H10O4
Molecular Weight 182.173
Flash Point 120.9±15.8 °C
Exact Mass 182.057907
PSA 55.76000
LogP 1.99
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.533
Storage condition Refrigerator
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG8598750
CHEMICAL NAME :
Benzoic acid, 3,4-dimethoxy-
CAS REGISTRY NUMBER :
93-07-2
BEILSTEIN REFERENCE NO. :
0518285
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H10-O4
MOLECULAR WEIGHT :
182.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
1 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DG8598750
HS Code 2918990090
HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:93-07-2 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 93-07-2 | Chemsrc address: https://m.chemsrc.com/en/baike/1188380.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved