7432-28-2
7432-28-2 structure
- Name: Schisandrol A
- Chemical Name: Schisandrin
- CAS Number: 7432-28-2
- Molecular Formula: C24H32O7
- Molecular Weight: 432.507
- Catalog: Biochemical Plant extracts
- Create Date: 2018-03-16 08:00:00
- Modify Date: 2026-07-31 21:43:27
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Schisandrin has various therapeutic effects on a range of medical conditions such as anti-asthmatic, anti-cancer, and anti-inflammatory effects.IC50 value:Target:in vitro: Sch inhibited the pro-fibrotic activity of TGF-β1 in AML12 cells; thus, it suppressed the accumulation of ECM proteins. Also, Sch inhibited the EMT as assessed by reduced expression of vimentin and fibronectin, and increased E-cadherin and ZO-1 in TGF-β1 induced AML12 cells. Sch reduced TGF-β1-mediated phosphorylation of Smad2/3 and Smad3/4 DNA binding activity. On the other hand, Sch reduced TGF-β1-induced ERK1/2 and PI3K/Akt phosphorylation in the non-Smad pathway [1]. the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide (NO) production, prostaglandin E(2) (PGE(2)) release, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, which in turn results from the inhibition of nuclear factor-kappaB (NF-kappaB), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activities in a RAW 264.7 macrophage cell line [2].
| Name | Schisandrin |
|---|---|
| Synonyms |
Abametapir Impurity 29
chisandrin 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol schizandra SCHISANDRIN Extractum Schisandrae chinensis Schisandrin,Schizandrin SCHIZANDRIN Schisandrinum Schizandrin from Schisandra chinensis (Turcz.) Baill (6S,7S,12-1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c]annulen-6-ol SCHIZANDROL Schisandrae Berry Extract 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol 1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-,(6S,7S hot selling Schisandra Berries P.E Schisandrol Schisandra schisandrins Schisandrol A 7-2 WUWEIZI ALCOHOL A Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro 12) Schisandrin (Schizandrol SCHISANDROL A Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7S,12) Schisandrin（Schizandrol A） DeoxyschizandrinSchisandra chinensis extract SCHIZANDROL A Schizandrin std (+)-Schizandrin Schisandrin Schisandrine Wuweizi alcohol A Schizandrin dibenzo(a,c)cycloocten-6-ol,5,6,7,8-tetrahydro-6,7-dimethyl-1,23,10,11,12-hex 5,6,7,8-Tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-6-ol Schisandrin, 10 mM in DMSO Schisadrol A SCHISANDRIN (SCHISANDROL A) Schisandrin methyl Schizandrin 1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol Schizandrin, >= Schisandrol A structure |
| Description | Schisandrin has various therapeutic effects on a range of medical conditions such as anti-asthmatic, anti-cancer, and anti-inflammatory effects.IC50 value:Target:in vitro: Sch inhibited the pro-fibrotic activity of TGF-β1 in AML12 cells; thus, it suppressed the accumulation of ECM proteins. Also, Sch inhibited the EMT as assessed by reduced expression of vimentin and fibronectin, and increased E-cadherin and ZO-1 in TGF-β1 induced AML12 cells. Sch reduced TGF-β1-mediated phosphorylation of Smad2/3 and Smad3/4 DNA binding activity. On the other hand, Sch reduced TGF-β1-induced ERK1/2 and PI3K/Akt phosphorylation in the non-Smad pathway [1]. the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide (NO) production, prostaglandin E(2) (PGE(2)) release, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, which in turn results from the inhibition of nuclear factor-kappaB (NF-kappaB), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activities in a RAW 264.7 macrophage cell line [2]. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 576.7±50.0 °C at 760 mmHg |
| Melting Point | 128-129ºC |
| Molecular Formula | C24H32O7 |
| Molecular Weight | 432.507 |
| Flash Point | 302.6±30.1 °C |
| Exact Mass | 432.214813 |
| PSA | 75.61000 |
| LogP | 4.18 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.535 |
| Storage condition | room temp |
| Water Solubility | DMSO: ≥13mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Codes | Xn,N |
| Risk Phrases | 22-50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| Hazard Class | 9.0 |
| HS Code | 2932999099 |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |