Manool

Modify Date: 2025-08-20 17:24:48

Manool structure	Common Name	Manool
	CAS Number	596-85-0	Molecular Weight	290.48300
	Density	0.93g/cm3	Boiling Point	368.2ºC at 760mmHg
	Molecular Formula	C₂₀H₃₄O	Melting Point	49-52ºC(lit.)
	MSDS	N/A	Flash Point	118.2ºC

Use of Manool

Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].

Name	manool
Synonym	More Synonyms

Description	Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 µg/mL) and U343 (IC50=6.7 µg/mL) cells[1]. Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells[3].
References	[1]. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143. [2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290. [3]. Nicolella HD, et al. Differential effect of manool--a diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells. Food Chem Toxicol. 2014;72:8-12.

Density	0.93g/cm3
Boiling Point	368.2ºC at 760mmHg
Melting Point	49-52ºC(lit.)
Molecular Formula	C₂₀H₃₄O
Molecular Weight	290.48300
Flash Point	118.2ºC
Exact Mass	290.26100
PSA	20.23000
LogP	5.50240
Index of Refraction	1.5
InChIKey	CECREIRZLPLYDM-ZYKFHVCXSA-N
SMILES	C=CC(C)(O)CCC1C(=C)CCC2C(C)(C)CCCC12C

Manool MSDS(Chinese)

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3

sclareol 8-acetate

CAS#:22628-62-2

~91%

Manool

CAS#:596-85-0

Literature: Rogachev, Victor; Loehl, Thorsten; Markert, Thomas; Metz, Peter Arkivoc, 2012 , vol. 2012, # 3 p. 172 - 180

Geranylgeranyl ...

CAS#:6699-20-3

~15%

Manool

CAS#:596-85-0

Manool

CAS#:596-85-0

(+)-Copalol

CAS#:10395-43-4

Literature: Organic and Biomolecular Chemistry, , vol. 9, # 7 p. 2156 - 2165

Sclareol

CAS#:515-03-7

Manool

CAS#:596-85-0

Literature: Arkivoc, , vol. 2012, # 3 p. 172 - 180

1-Naphthalenepr...

CAS#:54274-72-5

Manool

CAS#:596-85-0

Literature: Arkivoc, , vol. 2012, # 3 p. 172 - 180

(+)-3α-hydroxymanool

CAS#:112239-38-0

Manool

CAS#:596-85-0

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 453 - 458

Sclareol

CAS#:515-03-7

(3R,4aS,6aR,10a...

CAS#:596-84-9

15,16-Dinor-8(1...

CAS#:10266-75-8

Manool

CAS#:596-85-0

Literature: Agricultural and Biological Chemistry, , vol. 46, # 10 p. 2477 - 2484

Sclareol

CAS#:515-03-7

Ethanoic anhydride

CAS#:108-24-7

acetic acid

CAS#:64-19-7

labda-8(20),13ξ...

CAS#:84026-14-2

Detail

Literature: Justus Liebigs Annalen der Chemie, , vol. 617, p. 134 Journal of the Chemical Society, , p. 2187,2189

Precursor 7
CAS#:22628-62-2 sclareol 8-acetate CAS#:6699-20-3 Geranylgeranyl ... CAS#:515-03-7 Sclareol CAS#:54274-72-5 1-Naphthalenepr...
CAS#:112239-38-0 (+)-3α-hydroxymanool CAS#:108-24-7 Ethanoic anhydride CAS#:64-19-7 acetic acid
DownStream 6
CAS#:3243-36-5 (1S,4aS,8aS)-De... CAS#:511-15-9 Totarol CAS#:515-03-7 Sclareol CAS#:1232-00-4 13-epi-sclareol
CAS#:2584-47-6 1,4-Dimethyl-2(... CAS#:641-91-8 1,2,5-trimethyl...

Name: Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as redu...
Source: ChEMBL
Target: B16-F10
External Id: CHEMBL5145698

Name: Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse bearing assessed...
Source: ChEMBL
Target: B16-F10
External Id: CHEMBL5145699

Name: Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5145700

Name: Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5145701

Name: Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as redu...
Source: ChEMBL
Target: B16-F10
External Id: CHEMBL5145694

Name: Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as redu...
Source: ChEMBL
Target: B16-F10
External Id: CHEMBL5145695

Name: Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as redu...
Source: ChEMBL
Target: B16-F10
External Id: CHEMBL5145696

Name: Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as redu...
Source: ChEMBL
Target: B16-F10
External Id: CHEMBL5145697

Name: Cytotoxicity against human HL cells assessed as cell viability at 50 uM after 72 hrs ...
Source: ChEMBL
Target: HL
External Id: CHEMBL4135472

Name: Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as redu...
Source: ChEMBL
Target: B16-F10
External Id: CHEMBL5145690

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8,14-labdadien-13-ol

MFCD01310996

MANOOL

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Manool
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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Price: ￥2500/50 mg

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Manool

Use of Manool

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Precursor & DownStream

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Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.