120166-69-0
120166-69-0 structure
- Name: R59949
- Chemical Name: 3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
- CAS Number: 120166-69-0
- Molecular Formula: C28H25F2N3OS
- Molecular Weight: 489.57900
- Catalog: Signaling Pathways Epigenetics PKC
- Create Date: 2018-05-22 08:00:00
- Modify Date: 2026-07-01 18:08:02
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R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol[1][2][3].
| Name | 3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one |
|---|---|
| Synonyms |
MFCD00069258
R59949, 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone 4(1H)-Quinazolinone, 3-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo DIACYLGLYCEROL KINASE INHIBITOR I DAG Kinase Inhibitor DAG Kinase Inhibitor II Diacylglycerol Kinase Inhibitor II solid Diacylglycerol Kinase Inhibitor II - - Calbiochem 3-[2-(4-[BIS(4-FLUOROPHENYL)-METHYLENE)-1-PIPERIDINYL)ETHYL]-2,3-DIHYDRO-2-THIOXO-4[1H]-QUINAZOLINONE 3-[2-[4-Bis(4-fluorophenyl)methyleniperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one R59949 ，E0082 3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone R59949, 10 mM in DMSO R-59949(R-59-949) kinase,endogenous,PKC,plasma,platelet,diacylglycerol,Protein kinase C,Inhibitor,R59949,inhibit,ligand,membranes 3-[2-[4-(bis(4-Fluorophenyl)Methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, R59949 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one Diacylglycerol Kinase Inhibitor II DIACYLGLYCEROL KINASE INHIBITOR II |
| Description | R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | In the presence of R59949, vasopressin- as well as collagen-induced release reaction and aggregation was strongly increased, independently of the formation of arachidonate metabolites[1]. In THP‐1 monocytes, R59949 attenuates CCL2‐evoked Ca2+ signalling with a half‐maximal concentration of 8.6 μM[2]. R59949 inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells[4]. |
| References |
| Density | 1.36g/cm3 |
|---|---|
| Boiling Point | 637.1ºC at 760mmHg |
| Molecular Formula | C28H25F2N3OS |
| Molecular Weight | 489.57900 |
| Flash Point | 339.1ºC |
| Exact Mass | 489.16900 |
| PSA | 73.12000 |
| LogP | 5.87310 |
| Vapour Pressure | 3.94E-16mmHg at 25°C |
| Index of Refraction | 1.688 |
| Storage condition | -20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |