59-42-7
59-42-7 structure
- Name: (R)-(-)-Phenylephrine
- Chemical Name: phenylephrine
- CAS Number: 59-42-7
- Molecular Formula: C9H13NO2
- Molecular Weight: 167.20500
- Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
- Create Date: 2018-09-30 20:02:25
- Modify Date: 2024-01-02 16:50:51
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(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.
| Name | phenylephrine |
|---|---|
| Synonyms |
Neophryn
Mydfrin Mesatone Mesaton Phenylephrine Nostril EINECS 200-424-8 MFCD00044749 Mezaton Adrianol Isophrin Prefrin (R)-(-)-Phenylephrine |
| Description | (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant. |
|---|---|
| Related Catalog | |
| In Vitro | (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist with pKi values of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively[1][2]. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis[3]. |
| In Vivo | Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes[4]. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema[5]. |
| Animal Admin | Rats: A total of 170 male Wistar rats are randomLy allocated into 17 groups (n=10) using random number tables. Short-term (40 minutes) mechanical ventilation with high tidal volume is performed to induce lung injury, impair active Na+ transport and lung liquid clearance in the rats. Unventilated rats serves as controls. To demonstrate the effect of phenylephrine on alveolar fluid clearance, phenylephrine at different concentrations (10, 1, 0.1, 0.01, and 0.001 μM) is injected into the alveolar space of the HVT ventilated rats[5]. |
| References |
| Density | 1.159 g/cm3 |
|---|---|
| Boiling Point | 341.1ºC at 760 mmHg |
| Melting Point | 171°C |
| Molecular Formula | C9H13NO2 |
| Molecular Weight | 167.20500 |
| Flash Point | 163.4ºC |
| Exact Mass | 167.09500 |
| PSA | 52.49000 |
| LogP | 1.03590 |
| Index of Refraction | -55.5 ° (C=5, 1mol/L HCl) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xn |
|---|---|
| Risk Phrases | R22 |
| Safety Phrases | S26-S36-S45 |
| RTECS | DO7175000 |
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~%
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| Literature: WO2008/77560 A1, ; Page/Page column 10-11 ; |
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~89%
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| Literature: Divi's Laboratories Limited Patent: US2012/108848 A1, 2012 ; Location in patent: Page/Page column 4 ; |
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~10%
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| Literature: Lin, Wei-De; Chen, Chien-Yu; Chen, Huei-Chung; Hsu, Wen-Hwei Process Biochemistry, 2010 , vol. 45, # 9 p. 1529 - 1536 |
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~%
59-42-7 |
| Literature: Tetrahedron Asymmetry, , vol. 21, # 20 p. 2479 - 2486 |
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| Literature: Applied Catalysis A: General, , vol. 439-440, p. 74 - 79 |
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~%
59-42-7 |
| Literature: Applied Catalysis A: General, , vol. 439-440, p. 74 - 79 |
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59-42-7 |
| Literature: Monatshefte fuer Chemie, , vol. 80, p. 517,521,524,534 |
| Precursor 5 | |
|---|---|
| DownStream 2 | |
