178603-78-6

178603-78-6 structure

Name: Caspase-1 Inhibitor II
Chemical Name: ac-yvad-cmk
CAS Number: 178603-78-6
Molecular Formula: C₂₄H₃₃ClN₄O₈
Molecular Weight: 540.994
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2018-12-22 07:33:23
Modify Date: 2026-07-09 08:56:32
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2].

Name	ac-yvad-cmk
Synonyms	Ac-YVAD-cmk CASPASE-1 INHIBITOR (CHLOROMETHYLKETONE) IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(cboxymethyl)-3-chloro-2-oxopropyl] AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE CASPASE 1 INHIBITOR II;AC-YVAD-CMK interleukin-1β (il-1β) converting enzyme (ice) inhibitor ii Ac-YVAD-cmk >= (HPLC) AC-TYR-VAL-ALA-ASP-CH2CL ICE INHIBITOR II INTERLEUKIN-1BETA (IL-1BETA) CONVERTING ENZYME (ICE) INHIBITOR II (4S,7S,10S,13S)-13-(2-Chloroacetyl)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid AC-TYR-ALA-ASP-CHLOROMETHYLKETONE N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxo-2-butanyl]-L-alaninamide AC-TYR-VAL-ALA-ASP-CMK ; AC-YVKD-CMK interleukin-1B (1L-1B) converting*enzyme (ice) in (ACETYL-L-TYROSYL-L-VALYL-L-ALANYL-L-ASPT-1-YL)CHLOROMETHANE 5-Trihydroxybenzoic acid N-Ac-Tyr-Val-Ala-Asp-CMK N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KETONE N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KE AC-YVAD-CHLOROMETHYLKETONE Caspase-1 Inhibitor II - - Calbiochem INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR II AC-TYR-VAL-ALA-ASP-CMK AC-YVAD-CMK N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxobutan-2-yl]-L-alaninamide PASE-1 INHIBITOR II CASPASE-1 INHIBITOR II IL-1BETA CONVERTING ENZYME INHIBITOR II N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-1-(CBOXYMETHYL)-3-CHLORO-2-OXOPROPYL]-L-ALANINAMIDE Caspase 1 (ICE) Inhibitor II

Description	Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
Target	Caspase-1
In Vitro	Ac-YVAD-cmk (40 μM or 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia in vitro[2].
In Vivo	Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group[2]. Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis[3].
References	[1]. Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14(10):1245-1255. Published 2018 Jul 13. [2]. Liang H, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. Int Immunopharmacol. 2019;75:105771. [3]. Mathiak G, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000;131(3):383-386.

RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AY3079566