Caspase-1 Inhibitor II

Modify Date: 2024-01-02 13:30:59

Caspase-1 Inhibitor II structure	Common Name	Caspase-1 Inhibitor II
	CAS Number	178603-78-6	Molecular Weight	540.994
	Density	1.3±0.1 g/cm3	Boiling Point	969.1±65.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₃₃ClN₄O₈	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	539.9±34.3 °C

Use of Caspase-1 Inhibitor II

Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2].

Name	ac-yvad-cmk
Synonym	More Synonyms

Description	Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
Target	Caspase-1
In Vitro	Ac-YVAD-cmk (40 μM or 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia in vitro[2].
In Vivo	Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group[2]. Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis[3].
References	[1]. Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14(10):1245-1255. Published 2018 Jul 13. [2]. Liang H, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. Int Immunopharmacol. 2019;75:105771. [3]. Mathiak G, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000;131(3):383-386.

Density	1.3±0.1 g/cm3
Boiling Point	969.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₄H₃₃ClN₄O₈
Molecular Weight	540.994
Flash Point	539.9±34.3 °C
Exact Mass	540.198669
PSA	191.00000
LogP	1.93
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.554
Storage condition	-20°C

RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AY3079566

Ac-YVAD-cmk

N-Ac-Tyr-Val-Ala-Asp-CMK

AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE

AC-YVAD-CHLOROMETHYLKETONE

AC-TYR-VAL-ALA-ASP-CH2CL

AC-TYR-VAL-ALA-ASP-CMK

N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxobutan-2-yl]-L-alaninamide

PASE-1 INHIBITOR II

ICE INHIBITOR II

IL-1BETA CONVERTING ENZYME INHIBITOR II

L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-

AC-TYR-ALA-ASP-CHLOROMETHYLKETONE

N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxo-2-butanyl]-L-alaninamide

DC Chemicals Limited
China
Product Name: Ac-YVAD-cmk
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Nanjing Peptide Biotech Ltd
China
Product Name: Ac-Tyr-Val-Ala-Asp-chloromethylketone
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Taiwan Oyi peptide Co. Ltd
China
Product Name: AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

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Caspase-1 Inhibitor II

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