3,6-Dioxaoctanedioic acid

Modify Date: 2024-01-02 18:52:30

3,6-Dioxaoctanedioic acid Structure
3,6-Dioxaoctanedioic acid structure
Common Name 3,6-Dioxaoctanedioic acid
CAS Number 23243-68-7 Molecular Weight 178.14000
Density 1.375g/cm3 Boiling Point 429.2ºC at 760mmHg
Molecular Formula C6H10O6 Melting Point 68-71℃
MSDS N/A Flash Point 182.6ºC

 Use of 3,6-Dioxaoctanedioic acid


36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-(carboxymethoxy)ethoxy]acetic acid
Synonym More Synonyms

 3,6-Dioxaoctanedioic acid Biological Activity

Description 36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.375g/cm3
Boiling Point 429.2ºC at 760mmHg
Melting Point 68-71℃
Molecular Formula C6H10O6
Molecular Weight 178.14000
Flash Point 182.6ºC
Exact Mass 178.04800
PSA 93.06000
Vapour Pressure 1.43E-08mmHg at 25°C
Index of Refraction 1.474
Storage condition Store below +30°C.

 Safety Information

Hazard Codes C: Corrosive;
Risk Phrases R34
Safety Phrases 26-36/37/39-45-27-22
RIDADR UN 3261
Packaging Group III
HS Code 2918990090

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

2,2'-(ethane-1,2-diylbis(oxy))diacetic acid
3,6-dioxaoctadioic acid
3,6-dioxoctanedioic acid
3,6-dioxa-1,8-octanedioic acid
3,6-dioxaoctane-1,8-dioic acid
3,6-DIOXAOCTANEDIOIC ACID
(2-carboxymethoxyethoxy)acetic acid
3,6-dioxaoctandioic acid
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