191330-56-0

191330-56-0 structure

Name: Ezetimibe Ketone
Chemical Name: (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one
CAS Number: 191330-56-0
Molecular Formula: C₂₄H₁₉F₂NO₃
Molecular Weight: 407.409
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-12-23 20:31:41
Modify Date: 2026-07-01 21:02:53
Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3].

Name	(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one
Synonyms	EZM-K (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxo-propyl]-4-(4-hydroxyphenyl)-2-azetidinone Ezetimibe Impurity Ketone (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)-propyl]-4-(S)-(4-hydroxyphenyl)azetidin-2-one AZE016 trans-1-(4-Fluoro-phenyl)-3-[3-(4-fluoro-phenyl)-3-oxo-propyl]-4-(4-hydroxy-phenyl)-azetidin-2-one (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-azetidin-2-one EzetiMibe 3-Oxo IMpurity (3R,4S)-1-(4-Fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-on Ezetimibe Impurity 12 EzetimibeKetone impurity 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-, (3R,4S) Monophenyl phosphite diisooctyl 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)propyl]-4-(S)-(4-hydroxyphenyl)-2-azetidinone 1-(4-Fluorophenyl-3R-[3-(4-Fluorophenyl-3-Oxo-Propyl]-4S-(4-Hydroxyphenyl-AzetidiN-2-One ETMB-07 EZETIMIBE KETONE / EZETIMIBE 3-OXO IMPURITY EzetiMibe Ketone 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3-oxopropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone Ezetimibe Impurity 16(SCH57871) EzetimibeKetone Ezetimibe-1 Ezetimibe Impuriry A Ezetimib Ketone Impurity Ezetimibe impuriry 3/Ezetimibe Ketone/(3R,4S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one Ezetimium cloth impurity A Ezetimibe Intermediate-X

Description	Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy
Target	NPC1L1, Nrf2[1]
References	[1]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

Density	1.325
Boiling Point	656.1±55.0 °C at 760 mmHg
Molecular Formula	C₂₄H₁₉F₂NO₃
Molecular Weight	407.409
Flash Point	350.6±31.5 °C
Exact Mass	407.133301
PSA	57.61000
LogP	3.79
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.615

Hazard Codes	Xi

Precursor 4
190595-65-4 204589-82-2 204589-80-0 70627-52-0
DownStream 3
163222-32-0 163222-33-1 163380-16-3

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