Ezetimibe Ketone

Modify Date: 2025-08-20 11:37:16

Ezetimibe Ketone structure	Common Name	Ezetimibe Ketone
	CAS Number	191330-56-0	Molecular Weight	407.409
	Density	1.325	Boiling Point	656.1±55.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₁₉F₂NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	350.6±31.5 °C

Use of Ezetimibe Ketone

Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3].

Name	(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one
Synonym	More Synonyms

Description	Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy
Target	NPC1L1, Nrf2[1]
References	[1]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

Density	1.325
Boiling Point	656.1±55.0 °C at 760 mmHg
Molecular Formula	C₂₄H₁₉F₂NO₃
Molecular Weight	407.409
Flash Point	350.6±31.5 °C
Exact Mass	407.133301
PSA	57.61000
LogP	3.79
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.615

Hazard Codes	Xi

Precursor 4
CAS#:190595-65-4 (3R,4S)-4-[4-(B... CAS#:204589-82-2 (3R,4S)-3-Azeti... CAS#:204589-80-0 Methyl (3R,4S)-... CAS#:70627-52-0 N-(4-(Benzyloxy...
DownStream 3
CAS#:163222-32-0 4'-O-Benzyloxy ... CAS#:163222-33-1 Ezetimibe CAS#:163380-16-3 (R)-Ezetimibe

1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)-propyl]-4-(S)-(4-hydroxyphenyl)azetidin-2-one

1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3-oxopropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone

(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxo-propyl]-4-(4-hydroxyphenyl)-2-azetidinone

AZE016

(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone

(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one

1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)propyl]-4-(S)-(4-hydroxyphenyl)-2-azetidinone

2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-

(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-azetidin-2-one

Ezetimibe Intermediate-X

EzetiMibe Ketone

Ezetimibe Impurity 12

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Ezetimibe Ketone

Use of Ezetimibe Ketone

Names

Ezetimibe Ketone Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.