24991-53-5

24991-53-5 structure

Name: Polyethylene glycol diamine
Chemical Name: 2,2'-[1,2-Ethanediylbis(oxy)]diethanamine
CAS Number: 24991-53-5
Molecular Formula: (C₂H₄O)nC₄H₁₂N₂O
Molecular Weight: 1000(Average)
Catalog: Catalysts and additives Polyethylene glycol derivative
Create Date: 2018-06-17 10:56:53
Modify Date: 2024-01-06 19:23:50
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

Name	2,2'-[1,2-Ethanediylbis(oxy)]diethanamine
Synonyms	α,ω-Diamino Poly(Ethylene Glycol) MFCD00132004 Poly(ethylene glycol) diamine H2N-PEG-NH2 Polyethylene glycol diamine Poly(ethylene glycol) bis(amine)

Description	PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).
Related Catalog	Research Areas >> Cancer
References	[1]. Han X, et al. 9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro. Int J Pharm. 2009 May 8;372(1-2):125-31.

Density	1.003g/cm3
Boiling Point	241ºC at 760mmHg
Molecular Formula	(C₂H₄O)nC₄H₁₂N₂O
Molecular Weight	1000(Average)
Flash Point	>110℃
Exact Mass	148.12100
PSA	70.50000
LogP	0.33760
Appearance	Granular Solid \| White to off-white
Storage condition	−20°C
Water Solubility	Soluble in organic solvents. \| It is soluble in organic solvents. It is insoluble in water.

Symbol	GHS05, GHS08
Signal Word	Danger
Hazard Statements	H315-H317-H318-H334
Precautionary Statements	P261-P280-P305 + P351 + P338-P342 + P311
Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R36/37/38;R42/43
Safety Phrases	22-24/25-45-36/37-26
RIDADR	NONH for all modes of transport
WGK Germany	3