Polyethylene glycol derivative

Polyethylene glycol is a mixture of high molecular weights of ethylene glycol by intermolecular dehydration condensation. Depending on the relative molecular mass, the physical form of polyethylene glycol can range from white mucilage Mw 200-700) to waxy semi-solid (Mw 1000-2000) to hard waxy solid (Mw 3000 to 20000). Polyethylene glycol is soluble in most highly polar organic solvents such as alcohols, alcohol-silicon mixtures, glycols, esters, ketones, aromatic hydrocarbons, nitroalkanes, and the like. It is insoluble in aliphatic hydrocarbons, naphthenes and other organic solvents of low polarity polarity. The solubility of polyethylene glycol is related to its fraction and temperature relative to molecular mass. Liquid polyethylene glycol can be miscible with water in any proportion, while solid polyethylene glycol has only limited solubility, but even polyethylene glycol, which is the largest molecular weight fraction, has a solubility in water of more than 50%. When the temperature rises, the solubility of solid polyethylene glycol increases sharply. If the temperature is high enough (such as PEG-6000, 60 ° C), all the solid polyethylene glycols can be dissolved in any ratio with water. However, when the temperature continues to rise to near the boiling point of water, even a dilute solution will precipitate polyethylene glycol, and the precipitation temperature depends on the relative molecular mass and concentration of the polymer. When polyethylene glycol is mixed with water, a slight volume shrinkage occurs and a significant exotherm occurs. In addition, polyethylene glycol can also be dissolved in monomers of lower aldehydes, amines, organic acids, acid anhydrides, and polymers. However, it is insoluble in compounds containing long hydrocarbon chains such as rapeseed oil and mineral oil. Polyethylene glycol and polyethylene glycol fatty acid esters are widely used in the cosmetic industry and the pharmaceutical industry. Because polyethylene glycol has many excellent properties: water-soluble, non-volatile, physiologically inert, mild, lubricious and moisturizing, soft, and pleasant after use. Polyethylene glycols of different relative molecular mass fractions can be selected to alter the viscosity, hygroscopicity and texture of the article. Polyethylene glycol (Mr<2000) with low molecular weight is suitable as a wetting agent and consistency regulator for creams, lotions, toothpastes and shaving creams, as well as for non-cleaning hair care products. Gives hair a silky sheen. Polyethylene glycol (Mr>2000) with high molecular weight is suitable for lipsticks, deodorant sticks, soaps, shaving soaps, foundations and cosmetics. Among the cleaning agents, polyethylene glycol is also used as a suspending agent and a thickener. Used in the pharmaceutical industry as a base for ointments, creams, ointments, lotions and suppositories. Commercially available polyethylene glycols (eg, Polyethylene Glycol NF, Dow Chemical Co.) that are compatible with foods and pharmaceuticals are more suitable for cosmetic use. The use of methoxypolyethylene glycol and polypropylene glycol is similar to that of polyethylene glycol. In the Food Additives Supplement to the US Food, Drug, and Cosmetic Regulations, the food chemical Pharmacopoeia grade polyethylene glycol has been approved for use as a food additive either directly or indirectly. FAO/WHO 1985 specifies an ADI value of 0 to 10 mg/kg body weight. GRAS (FDA, §172.820, 1985). Acute oral toxicity (mouse) LD5033 ~ 35g / kg, intraperitoneal toxicity LD5010 ~ 13g / kg. Does not irritate the eyes, does not cause skin irritation and allergies.