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352439-37-3

352439-37-3 structure

352439-37-3 structure

Name: NH2-PEG8-OH
Chemical Name: 1-Aminooctaethylene Glycol
CAS Number: 352439-37-3
Molecular Formula: C₁₆H₃₅NO₈
Molecular Weight: 369.45100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-04-19 17:59:26
Modify Date: 2026-07-05 16:22:38
NH2-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-Aminooctaethylene Glycol
Synonyms	H2N-PEG8-OH/3,6,9,12,15,18,21-Htaoxatricosan-1-ol, 23-amino 1-AMinooctaethylene Glycol Amino-dPEG-OH 2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol 23-amino-3,6,9,12,15,18,21-htaoxatricosanol 3,6,9,12,15,18,21-Htaoxatricosan-1-ol, 23-amino Amino-dPEG-OH (QBD-10240) 1-amino-2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Amino-dPEG(R)8-OH 8-OH Amine-PEG8 Amino-PEG8-alcohol Amino-dPEG8-OH Amino-dPEG® NH2-PEG8-alcohol

Description	NH2-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₁₆H₃₅NO₈
Molecular Weight	369.45100
Exact Mass	369.23600
PSA	110.86000

Hazard Codes	Xi

352439-36-2 structure

352439-36-2

~90%

352439-37-3 structure

352439-37-3

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

112-60-7 structure

112-60-7

~%

352439-37-3 structure

352439-37-3

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

86770-67-4 structure

86770-67-4

~%

352439-37-3 structure

352439-37-3

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

134179-43-4 structure

134179-43-4

~%

352439-37-3 structure

352439-37-3

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

65883-12-7 structure

65883-12-7

~%

352439-37-3 structure

352439-37-3

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

125274-16-0 structure

125274-16-0

~%

352439-37-3 structure

352439-37-3

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

Precursor 6
352439-36-2 112-60-7 86770-67-4 134179-43-4
65883-12-7 125274-16-0
DownStream 0

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