DC Chemicals Limited
China
Product Name: Tr-PEG5
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
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Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

125274-16-0

125274-16-0 structure

Name: Tr-PEG4-OH
Chemical Name: 2-[2-[2-(2-trityloxyethoxy)ethoxy]ethoxy]ethanol
CAS Number: 125274-16-0
Molecular Formula: C₂₇H₃₂O₅
Molecular Weight: 436.54000
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-02-17 00:39:04
Modify Date: 2024-01-10 20:06:40
Tr-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Name	2-[2-[2-(2-trityloxyethoxy)ethoxy]ethoxy]ethanol
Synonyms	2-(2-(2-(2-(trityloxy)ethoxy)ethoxy)ethoxy)ethanol 2,5,8,11-Tetraoxatridecan-13-ol,1,1,1-triphenyl 13,13,13-triphenyl-3,6,9,12-tetraoxatridecan-1-ol Tr-PEG5 11-(triphenylmethyloxy)-3,6,9-trioxaundecan-1-ol 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol 13,13,13-triphenyl-3,6,9,12-tetraoxatridecanol tetraethylene glycol monotrityl ether TrtO-4eg-OH

Description	Tr-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Zhang Q, et al. Synthesis of a library of propargylated and PEGylated α-hydroxy acids toward "clickable" polylactides via hydrolysis of cyanohydrin derivatives. J Org Chem. 2014 Oct 17;79(20):9546-55.

Molecular Formula	C₂₇H₃₂O₅
Molecular Weight	436.54000
Exact Mass	436.22500
PSA	57.15000
LogP	4.03720

112-60-7

76-83-5

~99%

125274-16-0

Literature: Bondia, Andrea Molero; Larcher, Nicolas; Garrelly, Laurent; Rossi, Jean Christophe; Pascal, Robert Tetrahedron Letters, 2010 , vol. 51, # 25 p. 3330 - 3333

76-84-6

112-60-7

125274-16-0

Literature: Breyholz, Hans-Joerg; Wagner, Stefan; Faust, Andreas; Riemann, Burkhard; Hoeltke, Carsten; Hermann, Sven; Schober, Otmar; Schaefers, Michael; Kopka, Klaus ChemMedChem, 2010 , vol. 5, # 5 p. 777 - 789

112-60-7

76-83-5

~70%

76-84-6

125274-16-0

Literature: Gartiser, Thierry; Selve, Claude; Mansuy, Laurence; Robert, Alain; Delpuech, Jean-Jacques Journal of Chemical Research, Miniprint, 1984 , # 9 p. 2672 - 2691

Precursor 3
112-60-7 76-83-5 76-84-6
DownStream 7
352439-36-2 146462-60-4 22732-78-1 352439-37-3
6790-09-6 868594-48-3 477775-73-8

125274-16-0	1421933-37-0
26150-06-1	128660-97-9
134179-40-1	85141-94-2
133699-09-9	646068-80-6
637337-68-9	1334172-64-3