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41100-52-1

41100-52-1 structure
41100-52-1 structure
  • Name: memantine hydrochloride
  • Chemical Name: memantine hydrochloride
  • CAS Number: 41100-52-1
  • Molecular Formula: C12H22ClN
  • Molecular Weight: 215.763
  • Catalog: Biochemical Inhibitor Neuronal Signaling AMPA Receptor-kainate Receptor-NMDA Receptor Inhibitor
  • Create Date: 2018-02-06 08:00:00
  • Modify Date: 2024-01-02 10:10:33
  • Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3].
Name memantine hydrochloride
Synonyms 1,3-Dimethyl-5-aminoadamantane hydrochloride
Axura
3,5-Dimethyl-1-adamantanamine Hydrochloride
3,5-Dimethyladamantan-1-amine hydrochloride (1:1)
MFCD00214336
3,5-Dimethyltricyclo[3.3.1.1]decan-1-aminhydrochlorid
Ebixza
1-Amino-3,5-dimethyladamantane Hydrochloride
Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1)
3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride
Memantine Hydrochloride
3,5-diméthyltricyclo[3.3.1.1]décan-1-amine chlorhydrate
Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride
Ebixia
SUN Y7017
3,5-Dimethyl-1-adamantanamine hydrochloride (1:1)
EINECS 255-219-6
tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride
3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride (1:1)
MemantineHCl
3,5-Dimethyladamantan-1-amine hydrochloride
Memantine HCL
Akatinol
Menantine Hydrochloride
Memantine (hydrochloride)
Description Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3].
Related Catalog
References

[1]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34.

[2]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36.

[3]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46.
Boiling Point 239.8ºC at 760 mmHg
Melting Point 292 °C
Molecular Formula C12H22ClN
Molecular Weight 215.763
Flash Point 92.3ºC
Exact Mass 215.144073
PSA 26.02000
LogP 4.19640
Storage condition -20°C Freezer
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2921300090
HS Code 2921300090
Summary 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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