41100-52-1
41100-52-1 structure
- Name: memantine hydrochloride
- Chemical Name: memantine hydrochloride
- CAS Number: 41100-52-1
- Molecular Formula: C12H22ClN
- Molecular Weight: 215.763
- Catalog: Biochemical Inhibitor Neuronal Signaling AMPA Receptor-kainate Receptor-NMDA Receptor Inhibitor
- Create Date: 2018-02-06 08:00:00
- Modify Date: 2026-06-30 11:49:54
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Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3].
| Name | memantine hydrochloride |
|---|---|
| Synonyms |
3,5-DIMETHYL-TRICYCLO[3.3.1.13,7]DECAN-1-AMINE HYDROCHLORIDE
3,5-DIMETHYLAMANTADINE HYDROCHLORIDE 3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine,hydrochloride (1:1) Ebixza Memantine (hydrochloride) Memantine Hydrochloride MEMANTINE HCL Ebixia SUN Y7017 Dk Plum Fruit extract EINECS 255-219-6 Memantine hydrochloride (JAN/USAN) Akatinol, 3,5-Dimethyltricyclo-[3,3,1,13,7]decan-1-amine, 3,5-Dimethyl-1-adamantanamine Namenda (TN) MEMANTINE HCL(SH) 3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride 3,5-DIMETHYL-1-AMINOADAMANTANE HCL 3,5-Dimethyl-1-adamantanamine hydrochloride amantadine derivative 3,5-Dimethyltricyclo[3.3.1.1]decan-1-aminhydrochlorid MemantinHCl 1-Amino-3,5-dimethyladamantane Hydrochloride Memantin Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride Menantine Hydrochloride Memantine HCl (Namenda) tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride 1-AMINO-3,5-DIMETHYLADAMANTANE HCL MEMANTINE HCL(SG) Memantine hydrochloride 3,5 D-145 Namenda 3,5-DIMETHYL-1-ADAMANTANAMINE HYDROCHLORIDE EMANTINEHYDROCHLORIDE Akatinol LABOTEST-BB LT00233220 TIMTEC-BB SBB003390 3,5-Dimethyl-1-adamantanamine Hydrochloride 1-AMINO-3,4-DIMETHYLADAMANTANE HYDROCHLORIDE 3,5-Dimethyladamantane-1-amine·hydrochloride 1-AMINO-3,5-DIMETHYLADAMANTANE HYDROCHLORIDE Memantine hydrochloride [USAN] MFCD00214336 Memantine hydrochloride Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1) Menantine HCl 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride 1,3-Dimethyl-5-aminoadamantane hydrocloride Ebixa MENANTINE HYDROCHLORIDE 3,5-Dimethyl-1-adamantanamine hydrochloride (1:1) AKATINOL 3,5-DIMETHYL-1-ADAMANTANAMINE (3,5-dimethyl-1-adamantyl)amine hydrochloride Memantine hydrochloride, >= 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride (1:1) MemantineHCl 3,5-Dimethyladamantan-1-amine hydrochloride 3,5-dimethyladamantan-1-amine hydrochloride 1,3-DIMETHYLAMINOADAMANTANE HYDROCHLORIDE 3,5-Dimethyladamantanamine Hydrochloride Dk Plum Fruit、Smoked Plum、Dk Plum 1,3-Dimethyl-5-aminoadamantane hydrochloride 1-Amino-3,5-dimethyladamantane Hydrochloride Memantine Hydrochloride Axura MeMantine hydrochloride API 1,3-DiMethyl-5-aMinoadaMantane hydrochloride, R 3,5-Dimethyladamantan-1-amine hydrochloride (1:1) 3,5-dimethyladamantan-1-amine Ebony fruit extract Fructus Mume P.E 3,5-diméthyltricyclo[3.3.1.1]décan-1-amine chlorhydrate 1,3-Dimethyl-5-aminoadamantane Fructus Mume extract Memantine HCL 3,5-dimethyl-1-aminoadamantane hydrochloride SUN-Y-7017 |
| Description | Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3]. |
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| Related Catalog | |
| References |
| Boiling Point | 239.8ºC at 760 mmHg |
|---|---|
| Melting Point | 292 °C |
| Molecular Formula | C12H22ClN |
| Molecular Weight | 215.763 |
| Flash Point | 92.3ºC |
| Exact Mass | 215.144073 |
| PSA | 26.02000 |
| LogP | 4.19640 |
| Storage condition | -20°C Freezer |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2921300090 |
| Precursor 10 | |
|---|---|
| DownStream 1 | |
| HS Code | 2921300090 |
|---|---|
| Summary | 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |