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333-93-7

333-93-7 structure
333-93-7 structure
Name 1,4-Diaminobutane dihydrochloride
Synonyms 1,4-DIAMINOBUTANE 2HCL
1,4-BUTANEDIAMMONIUM DICHLORIDE
Putrescin dihydrochloride
TETRAMETHYLENEDIAMINE 2HCL
EINECS 206-375-9
butane-1,4-diamine dihydrochloride
PUTRESCINE HYDROCHLORIDE
Putrescine 2HCl
1,4-Butanediamine, hydrochloride (1:2)
DIAMINOBUTANE DIHYDROCHLORIDE
1,4-DiaMinobutane Dihydrochloride
1,4-Butanediamine dihydrochloride
1,4-DIAMINOBUTANE HYDROCHLORIDE
PUT dihydrochloride
MFCD00012526
Putrescine Dihydrochloride
butane-1,4-diaminium dichloride
Tetramethylenediamine Dihydrochloride
Description 1,4-Diaminobutane dihydrochloride is an endogenous metabolite, acts as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI) [1]. 1,4-Diaminobutane dihydrochloride is an important source of GABA[2].
Related Catalog
Target

Human Endogenous Metabolite[1]

In Vitro 1,4-Diaminobutane is an important source of GABA in the postnatal rat subventricular zone. GABA synthesis from an alternative pathway uses 1,4-Butanediamine as a precursor[2].
References

[1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.

[2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.
Density 1.472g/cm3
Boiling Point 159ºC at 760 mmHg
Melting Point 280 °C (dec.)(lit.)
Molecular Formula C4H14Cl2N2
Molecular Weight 161.073
Flash Point 51.7ºC
Exact Mass 160.053406
PSA 52.04000
LogP 2.68860
Storage condition 2-8°C
Stability Stable, but hygroscopic. Substances to be avoided: strong oxidizing agents. Combustible.
Water Solubility H2O: 100 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EJ7280000
CHEMICAL NAME :
1,4-Butanediamine, dihydrochloride
CAS REGISTRY NUMBER :
333-93-7
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C4-H12-N2.2Cl-H
MOLECULAR WEIGHT :
161.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1625 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD30 - Lethal Dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1880 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
2 mmol/L
REFERENCE :
JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 78,217,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1000 No. of Facilities: 81 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 236 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS EJ7280000
HS Code 2921290000
HS Code 2921290000
Summary 2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
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