2437-29-8

2437-29-8 structure

Name: Malachite green oxalate
Chemical Name: Basic Green 4
CAS Number: 2437-29-8
Molecular Formula: C₅₂H₅₄N₄O₁₂
Molecular Weight: 454.946
Catalog: Dyes and pigments dye Basic dye
Create Date: 2018-04-06 08:00:00
Modify Date: 2024-01-02 17:52:21
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].

Name	Basic Green 4
Synonyms	EINECS 219-441-7 4-{[4-(Dimethylamino)phenyl](phenyl)methylene}-N,N-dimethyl-2,5-cyclohexadien-1-iminium chloride - ethanedioic acid (1:1:1) 4,4'-bis-dimethylamino-tritylium,oxalate Malachite Green,Oxalate N-(4-{[4-(Dimethylamino)phenyl](phenyl)methylene}cyclohexa-2,5-dien-1-ylidene)-N-methylmethanaminium chloride ethanedioic acid (1:1:1) Malachite Green oxalate,high purity biological stain Basisgreen4 Malachite Green oxalate,certified OXALATE N-(4-{[4-(dimethylamino)phenyl](phenyl)methylidene}cyclohexa-2,5-dien-1-ylidene)-N-methylmethanaminium chloride - ethanedioic acid (1:1:1) MFCD00011766 Malachite green oxalate LIGHT GREEN N SOLID GREEN O malachite green,oxalate salt Ethanedioate BASIC GREEN 4,4'-Bis-dimethylamino-tritylium,Oxalat Carboxyformate Malachite green

Description	Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IKBKE[3]
References	[1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13. [2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91. [3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 56,43,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2442 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 112 (estimated) No. of Female Employees: 41 (estimated)

Symbol	GHS05, GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H301-H318-H361d-H410
Precautionary Statements	Missing Phrase - N15.00950417-P280-P305 + P351 + P338 + P310
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn;N
Risk Phrases	R22;R41;R50/53;R63
Safety Phrases	S26-S39-S45-S61-S60-S46-S36/37-S2-S36/37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	BQ1190000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	32041300

HS Code	32041300