521-61-9

521-61-9 structure

Name: Physcion
Chemical Name: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
CAS Number: 521-61-9
Molecular Formula: C₁₆H₁₂O₅
Molecular Weight: 284.26
Catalog: Biochemical Plant extracts
Create Date: 2018-07-11 11:26:38
Modify Date: 2024-01-02 12:27:21
Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].

Name	1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
Synonyms	1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione Emodin 3-methyl ether EINECS 208-315-7 MFCD00017374 Emodin monomethyl ether 9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl- Parietin Methoxyemodin 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione Emodin-3-methyl ether Rheochrysidin physicion phycion 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone Physcion 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone,Emodin-3-methyl ether 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone 1,8-dihydroxy-5-methyl-3-methoxy-9,10-anthraquinone Physcione

Description	Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 38.5 μM (6-phosphogluconate dehydrogenase)[1] Kd: 26.0 μM (6-phosphogluconate dehydrogenase)[1]
References	[1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. [2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.

Density	1.4±0.1 g/cm3
Boiling Point	560.5±50.0 °C at 760 mmHg
Melting Point	196-206°C
Molecular Formula	C₁₆H₁₂O₅
Molecular Weight	284.26
Flash Point	215.4±23.6 °C
Exact Mass	284.068481
PSA	83.83000
LogP	5.20
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.678
Storage condition	-20°C Freezer, Under Inert Atmosphere

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 27,1342,1979

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CB6720000
HS Code	2914699010

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%