215030-90-3

215030-90-3 structure

Name: BMS 493
Chemical Name: 4-{(E)-2-[5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydro-2-naphthalen yl]vinyl}benzoic acid
CAS Number: 215030-90-3
Molecular Formula: C₂₉H₂₄O₂
Molecular Weight: 404.50000
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2016-08-19 03:49:33
Modify Date: 2024-01-08 00:21:04
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2].

Name	4-{(E)-2-[5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydro-2-naphthalen yl]vinyl}benzoic acid
Synonyms	4-[(E)-(5 6-Dihydro-5,5-dimethyl-8-phenylethynyl-2-naphthalenyl)ethenyl]benzoic acid (E)-4-[2-[2-[[(p-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine (E)-4-(2-(2-(N-(4-METHOXYBENZENESULFONYL)AMINO)PHENYL)VINYL)PYRIDINE (E)-4-[2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid Benzenesulfonamide,4-methoxy-N-[2-[2-(4-pyridinyl)ethenyl]phenyl]-,(E) (E)-4-[2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalene-2-yl]ethen-1-yl]benzoic acid Benzenesulfonamide,4-methoxy-N-[2-[(1E)-2-(4-pyridinyl)ethenyl]phenyl] (E)-4-[2-{2-[N-(4-methoxybenzenesulfonyl)amino]phenyl}ethenyl ]pyridine (E)-4-[2-[2-[N-[(p-Methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine (E)-4-[2-[2-(p-methoxy-benzene-sulfonamide)phenyl]ethenyl]pyridine BMS-204493

Description	BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RAR
In Vitro	BMS493 (100 nM; 6 days; ALDHhi UCB cells) treatment shows a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. Newly expanded ALDHhi cells shows increased numbers of CD34 and CD133-positive cells, as well as a reduction in CD38 expression, a marker of hematopoietic cell differentiation[1]. Cell Viability Assay[1] Cell Line: ALDHhi UCB cells Concentration: 100 nM Incubation Time: 6 days Result: Showed a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls.
In Vivo	Intrapancreatic transplantation of cell progeny after expansion of ALDHhi cells with or without BMS493 shows no reduction of hyperglycemia in Streptozotocin-treated NOD/SCID mice. Thus, Umbilical cord blood (UCB)-derived ALDHhi cells effectively lost islet regenerative capacity during ex vivo expansion[1].
References	[1]. Elgamal RM, et al. BMS 493 Modulates Retinoic Acid-Induced Differentiation During Expansion of Human Hematopoietic Progenitor Cells for Islet Regeneration. Stem Cells Dev. 2018 Aug 1;27(15):1062-1075. [2]. Yu Z, et al. Apoptosis induced by atRA in MEPM cells is mediated through activation of caspase and RAR. Toxicol Sci. 2006 Feb;89(2):504-9.

Molecular Formula	C₂₉H₂₄O₂
Molecular Weight	404.50000
Exact Mass	404.17800
PSA	37.30000
LogP	6.67160

Hazard Statements	H413
RIDADR	NONH for all modes of transport

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