123226-28-8

123226-28-8 structure

Name: [3-(quinolin-2-ylmethoxy)phenyl]methanol
Chemical Name: [3-(quinolin-2-ylmethoxy)phenyl]methanol
CAS Number: 123226-28-8
Molecular Formula: C₁₇H₁₅NO₂
Molecular Weight: 265.30700
Catalog: Signaling Pathways GPCR/G Protein GPCR19
Create Date: 2016-05-18 22:35:18
Modify Date: 2024-01-09 13:17:45
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].

Name	[3-(quinolin-2-ylmethoxy)phenyl]methanol
Synonyms	3-(2-quinolinylmethyloxy)benzyl alcohol 2-(3-hydroxymethylphenoxy)methylquinoline 3-(2-quinolinylmethoxy)benzyl alcohol 3-(quinol-2-ylmethoxy)benzyl alcohol 3-(Quinolin-2-ylmethoxy)benzyl alcohol [3-(quinolin-2-ylmethoxy)-phenyl]-methanol Benzenemethanol,3-(2-quinolinylmethoxy)

Description	CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Signaling Pathways >> GPCR/G Protein >> GPCR19 Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	CysLT1:2.80 ± 0.3 μM (IC50) TNF-α
References	[1]. Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529.