[3-(quinolin-2-ylmethoxy)phenyl]methanol

Modify Date: 2024-01-09 13:17:45

[3-(quinolin-2-ylmethoxy)phenyl]methanol structure	Common Name	[3-(quinolin-2-ylmethoxy)phenyl]methanol
	CAS Number	123226-28-8	Molecular Weight	265.30700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₅NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [3-(quinolin-2-ylmethoxy)phenyl]methanol

CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].

Name	[3-(quinolin-2-ylmethoxy)phenyl]methanol
Synonym	More Synonyms

Description	CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Signaling Pathways >> GPCR/G Protein >> GPCR19 Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	CysLT1:2.80 ± 0.3 μM (IC50) TNF-α
References	[1]. Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529.

Molecular Formula	C₁₇H₁₅NO₂
Molecular Weight	265.30700
Exact Mass	265.11000
PSA	42.35000
LogP	3.30610

3-(2-quinolinylmethyloxy)benzyl alcohol

2-(3-hydroxymethylphenoxy)methylquinoline

3-(2-quinolinylmethoxy)benzyl alcohol

3-(quinol-2-ylmethoxy)benzyl alcohol

3-(Quinolin-2-ylmethoxy)benzyl alcohol

[3-(quinolin-2-ylmethoxy)-phenyl]-methanol

Benzenemethanol,3-(2-quinolinylmethoxy)

[3-(quinolin-2-ylmethoxy)phenyl]methanol

Use of [3-(quinolin-2-ylmethoxy)phenyl]methanol

Names

[3-(quinolin-2-ylmethoxy)phenyl]methanol Biological Activity

Chemical & Physical Properties

Synonyms