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China
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Shanghai Jizhi Biochemical Technology Co., Ltd
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DC Chemicals Limited
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Henan Tianfu Chemical Co., Ltd.
China
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130-85-8

130-85-8 structure

Name: Pamoic acid
Chemical Name: pamoic acid
CAS Number: 130-85-8
Molecular Formula: C₂₃H₁₆O₆
Molecular Weight: 388.38
Catalog: analytical chemistry food safety Fatty acid, fatty acid methyl ester
Create Date: 2018-05-26 08:00:00
Modify Date: 2024-01-02 07:28:11
Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].

Name	pamoic acid
Synonyms	Pamoic 1,1'-Methylene-bis(2-hydroxy-3-naphthoic acid) 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy- 4,4-Methylenebis(3-Hydroxy-2-Naphthoic Acid) EMBIONIC ACID PAMOIC ACID FREE ACID 2,2'-Dihydroxy-1,1'-dinaphthylmethane-3,3'-dicarboxylic Acid 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) Pamoic acid PAMOIC ACID pure Embonic acid 4,4'-Methylenedi(3-hydroxy-2-naphthoic Acid) EINECS 204-998-0 MFCD00004079

Description	Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	EC50: 79 nM (GPR35)[1]
In Vitro	GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes[1].
In Vivo	In a mouse model of stroke, that GPR35 activation by Pamoic acid (s.c.; 50-100 mg/kg) is neuroprotective. Pharmacological inhibition of GPR35 reveals that Pamoic acid reduces infarcts size in a GPR35 dependent manner. Pamoic acid treatment results in a preferential increment of noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain along with the reduced neutrophil counts[1].
References	[1]. Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10(1):9400. [2]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8.

Density	1.5±0.1 g/cm3
Boiling Point	642.7±55.0 °C at 760 mmHg
Melting Point	≥300 °C (dec.)
Molecular Formula	C₂₃H₁₆O₆
Molecular Weight	388.38
Flash Point	356.5±28.0 °C
Exact Mass	388.094696
PSA	115.06000
LogP	6.35
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.782
Water Solubility	PRACTICALLY INSOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL2180000

CHEMICAL NAME :: 2-Naphthoic acid, 4,4'-methylenebis(3-hydroxy-

CAS REGISTRY NUMBER :: 130-85-8

BEILSTEIN REFERENCE NO. :: 0901319

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C23-H16-O6

MOLECULAR WEIGHT :: 388.39

WISWESSER LINE NOTATION :: L66J CQ DVQ B1- BL66J CQ DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,381,1978

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	QL2180000
HS Code	2917399090

50-00-0

92-70-6

~95%

130-85-8

Literature: Journal of Organic Chemistry, , vol. 61, # 11 p. 3865 - 3869

50-00-0

64-19-7

92-70-6

130-85-8

Literature: Chemische Berichte, , vol. 34, p. 4148 Chemische Berichte, , vol. 25, p. 3215 Chemische Berichte, , vol. 61, p. 1001

Precursor 3
50-00-0 92-70-6 64-19-7
DownStream 3
6640-22-8 10075-24-8 49609-90-7

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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