1130067-06-9

1130067-06-9 structure

Name: VU0155069
Chemical Name: (S)-WAY 100135 dihydrochloride
CAS Number: 1130067-06-9
Molecular Formula: C₂₆H₂₇ClN₄O₂
Molecular Weight: 462.97100
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2016-10-08 17:16:28
Modify Date: 2024-01-27 20:25:13
VU0155069 (CAY10593), compound 69, is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro[1]. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays[2].

Name	(S)-WAY 100135 dihydrochloride

Description	VU0155069 (CAY10593), compound 69, is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro[1]. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Target	PLD1:46 nM (IC50) PLD2:933 nM (IC50)
References	[1]. Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17. [2]. Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20.

Hazard Codes	Xi