VU0155069

Modify Date: 2025-08-22 15:14:24

VU0155069 Structure
VU0155069 structure
Common Name VU0155069
CAS Number 1130067-06-9 Molecular Weight 462.97100
Density N/A Boiling Point N/A
Molecular Formula C26H27ClN4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU0155069


VU0155069 (CAY10593), compound 69, is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro[1]. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays[2].

 Names

Name (S)-WAY 100135 dihydrochloride

 VU0155069 Biological Activity

Description VU0155069 (CAY10593), compound 69, is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro[1]. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays[2].
Related Catalog
Target

PLD1:46 nM (IC50)

PLD2:933 nM (IC50)

References

[1]. Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17.

[2]. Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20.

 Chemical & Physical Properties

Molecular Formula C26H27ClN4O2
Molecular Weight 462.97100
Exact Mass 462.18200
PSA 70.13000
LogP 4.92040

 Safety Information

Hazard Codes Xi
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