3376-24-7
3376-24-7 structure
- Name: n-tert-butyl-n-[(e)-phenylmethylene]amine oxide
- Chemical Name: N-TERT-BUTYL-α-PHENYLNITRONE
- CAS Number: 3376-24-7
- Molecular Formula: C11H15NO
- Molecular Weight: 177.243
- Catalog: Chemical reagent Organic reagent 肟
- Create Date: 2018-07-10 19:08:41
- Modify Date: 2026-07-02 11:46:43
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N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[1][2][3][4].
| Name | N-TERT-BUTYL-α-PHENYLNITRONE |
|---|---|
| Synonyms |
n-benzylidene-tert-butylamineoxide
n-tert-butyl-2-phenylnitrone N-Benzylidene-2-methylpropan-2-amine oxide N-TERT-BUTYL-A-PHENYLNITRONE FOR SYNTHES N-tert-B-butyl-alpha-phenylnitrone n-tert-butyl-à-phenylnitrone 2-Methyl-N-(phenylmethylene)-2-propanamine N-oxide (E)-tert-butyl(oxido)(phenylmethylidene)azanium N-benzylidene-tert-butylamine N-oxide N-tert-Butyl-α-phenylnitrone(PBN) c-phenyl-n-tert-butylnitrone N-benzyliden-tert-butylamine N-ether 2-methyl-n-(phenylmethylene)-2-propanaminn-oxide N-tert-Butyl-α-phenylnitrone - - Calbiochem N-tert-Butyl-α-phenylnitrone,N-Benzylidene-tert-butylamine N-oxide, PBN, Phenyl N-t-butylnitrone n-tert-butyl-α-phenylnitrone n-tert-butyl-alpha-phenyl-nitron 2-Phenylethenyl phenyl sulfone BENZYLIDENE(TERT-BUTYL)AMMONIUMOLATE n-tert-butyl-c-phenylnitrone N-TERT-BUTYL-A-PHENYLNITRONE N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide N-T-BUTYL-A-PHENYLNITRONE N-benzylidene-t-butylamine N-oxide N-BENZYLIDENE-TERT-BUTYLAMINE N-OXIDE N-tert-Butyl-alpha-phenylnitrone à-phenyl-n-tert-butylnitrone N-Benzylidene-tert-butylamine N-oxide,PBN,Phenyl N-t-butylnitrone N-tert-Butyl-ɑ-phenylnitrone Butylphenylnitrone Styryl phenyl sulfone N-TERT-BUTYL-ALPHA-PHENYLNITRONE 2-phenyl-n-tert-butylnitrone tert-Butyl(benzylidene)amine N-oxide Benzylidene-tert-butylamine oxide EINECS 222-168-6 PHENYL-TERT-BUTYLNITRONE 2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide N-tert-butyl-α-Phenylnitrone, 10 mM in DMSO alpha-phenyl-n-tert-butylnitrone phenyl t-butyl nitrone 2-Methyl-N-(phenylmethylene)-2-propanamine oxide N-tert-Butyl-alpha-phenylnitrone, R N-tert-Butyl-α-phenylnitrone Benzylidene(tert-butyl)azane oxide N-TERT-BUTYL-ALPHA-PHENYLNITRONE (PNB) N-benzylidene-2-methylpropane-2-amine oxide 2-methyl-n-(phenylmethylene)-s-propanaminen-oxide N-tert-Butyl-alpha-phenylnitrone> MFCD00008799 N-T-BUTYL-ALPHA-PHENYLNITRONE Phenyl N-t-butylnitrone Phenyl-N-Tert-Butylnitrone [ PBN ] (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide PHENYL N-TERT-BUTYLNITRONE benzylidene-tert-butylaminen-oxide PHENYL TRANS-STYRYL SULFONE 99 2-methyl-n-(phenylmethylene)-s-propanaminn-oxide Azane, (1,1-dimethylethyl)(phenylmethylene)-, oxide |
| Description | N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[1][2][3][4]. |
|---|---|
| Related Catalog | |
| Target |
COX-2 Reactive oxygen species (ROS) |
| In Vitro | N-tert-Butyl-α-phenylnitrone (PBN) (25-100 µM) treatment leads to a significant decrease in 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-Butyl-α-phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis. N-tert-Butyl-α-phenylnitrone suppresses AAPH-induced activation of ERK/MAPK pathway. N-tert-Butyl-α-phenylnitrone has the potenial for intervertebral disc degeneration (IDD) research[1]. |
| In Vivo | N-tert-Butyl-α-phenylnitrone (PBN; 100 mg/kg; intraperitoneal injection; twice a day; C57Bl/6 mice) treatment not only abolishes the LPS-induced lipid peroxidation, nitrotyrosine residue levels, and GSH depletion, but also decreases the incidence of external malformations[2]. Animal Model: C57Bl/6 mice induced by lipopolysaccharide (LPS)[2] Dosage: 100 mg/kg Administration: Intraperitoneal injection; twice a day (on gestational day 8) Result: Abolished LPS-induced lipid peroxidation, nitrotyrosine residues, and GSH depletion. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 283.3±23.0 °C at 760 mmHg |
| Melting Point | 71-75ºC |
| Molecular Formula | C11H15NO |
| Molecular Weight | 177.243 |
| Flash Point | 118.5±15.4 °C |
| Exact Mass | 177.115356 |
| PSA | 28.75000 |
| LogP | 1.25 |
| Appearance | powder | white |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.552 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TX1760000 |
| HS Code | 2925290090 |
| Precursor 10 | |
|---|---|
| DownStream 8 | |
| HS Code | 2925290090 |
|---|---|
| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |