113122-54-6

113122-54-6 structure

Name: 3-Deoxysappanone B
Chemical Name: 3-(3,4-Dihydroxybenzyl)-7-hydroxy-2,3-dihydro-4H-chromen-4-one
CAS Number: 113122-54-6
Molecular Formula: C₁₆H₁₄O₅
Molecular Weight: 286.279
Catalog: Natural product Flavonoids
Create Date: 2017-04-21 10:10:13
Modify Date: 2024-06-22 09:47:32
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1].

Name	3-(3,4-Dihydroxybenzyl)-7-hydroxy-2,3-dihydro-4H-chromen-4-one
Synonyms	3-deoxysappanone B 4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methyl]-2,3-dihydro-7-hydroxy- 3-(3,4-Dihydroxybenzyl)-7-hydroxy-2,3-dihydro-4H-chromen-4-one

Description	Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. Ke-Wu Zeng, et al. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Eur J Pharmacol. 2015 Feb 5;748:18-29.

Hazard Codes	Xi