120011-66-7

120011-66-7 structure

Name: [D-Asp3]-Microcystin-LR
Chemical Name: (5R,8S,11R,15S,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,19-trimethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11
CAS Number: 120011-66-7
Molecular Formula: C₄₈H₇₂N₁₀O₁₂
Molecular Weight: 981.15
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2017-10-21 20:39:42
Modify Date: 2024-03-02 19:05:53
Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. Microcystin-[D-Asp3]-LR/Microcystin A can activate Nrf2 and promote oxidative stress response. Microcystin-[D-Asp3]-LR/Microcystin A can also be used in toxicology research[1][2].

Name	(5R,8S,11R,15S,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,19-trimethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11
Synonyms	Toxin II,cyanobacterium Cyclo-ala-leu-isoasp-arg-adda-isoglu-N-mdha

Description	Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. Microcystin-[D-Asp3]-LR/Microcystin A can activate Nrf2 and promote oxidative stress response. Microcystin-[D-Asp3]-LR/Microcystin A can also be used in toxicology research[1][2].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
In Vitro	Microcystin 的毒性主要靶向肠、肝、肾和生殖系统。其分子毒理学涉及蛋白磷酸酶的共价结合和抑制、氧化应激、细胞死亡（自噬、凋亡、坏死）和细胞骨架破坏[1]。 Microcystin-[D-Asp3]-LR/Microcystin A ([D-Asp3]-LR Microcystin) (1 μM) 显着增加 Nrf2 活性，从而表明氧化应激反应诱导[2]。
References	[1]. Arman T, et al. Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. Toxins (Basel). 2021 Jul 29;13(8):537. [2]. Lundqvist J, et al. Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins. Toxicon. 2017 Feb;126:47-50.