[D-Asp3]-Microcystin-LR

Modify Date: 2024-03-02 19:05:53

[D-Asp3]-Microcystin-LR Structure
[D-Asp3]-Microcystin-LR structure
Common Name [D-Asp3]-Microcystin-LR
CAS Number 120011-66-7 Molecular Weight 981.15
Density 1.3g/cm3 Boiling Point N/A
Molecular Formula C48H72N10O12 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of [D-Asp3]-Microcystin-LR


Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. Microcystin-[D-Asp3]-LR/Microcystin A can activate Nrf2 and promote oxidative stress response. Microcystin-[D-Asp3]-LR/Microcystin A can also be used in toxicology research[1][2].

 Names

Name (5R,8S,11R,15S,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,19-trimethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11
Synonym More Synonyms

 [D-Asp3]-Microcystin-LR Biological Activity

Description Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. Microcystin-[D-Asp3]-LR/Microcystin A can activate Nrf2 and promote oxidative stress response. Microcystin-[D-Asp3]-LR/Microcystin A can also be used in toxicology research[1][2].
Related Catalog
In Vitro Microcystin 的毒性主要靶向肠、肝、肾和生殖系统。其分子毒理学涉及蛋白磷酸酶的共价结合和抑制、氧化应激、细胞死亡(自噬、凋亡、坏死)和细胞骨架破坏[1]。 Microcystin-[D-Asp3]-LR/Microcystin A ([D-Asp3]-LR Microcystin) (1 μM) 显着增加 Nrf2 活性,从而表明氧化应激反应诱导[2]。
References

[1]. Arman T, et al. Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. Toxins (Basel). 2021 Jul 29;13(8):537.  

[2]. Lundqvist J, et al. Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins. Toxicon. 2017 Feb;126:47-50.  

 Chemical & Physical Properties

Density 1.3g/cm3
Molecular Formula C48H72N10O12
Molecular Weight 981.15
Exact Mass 980.53300
PSA 361.58000
LogP 3.36630
Index of Refraction 1.6

 Synonyms

Toxin II,cyanobacterium
Cyclo-ala-leu-isoasp-arg-adda-isoglu-N-mdha