957942-34-6

957942-34-6 structure

Name: TPNA10168
Chemical Name: Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-3-(methylsulfinyl)
CAS Number: 957942-34-6
Molecular Formula: C₉H₉ClO₂S₂
Molecular Weight: 248.75
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2016-09-10 17:49:55
Modify Date: 2024-03-01 18:38:47
TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases[1].

Name	Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-3-(methylsulfinyl)
Synonyms	1-chloro-3-(methylsulfinyl)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one

Description	TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
References	[1]. Izumi Y, et al. TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway. J Pharmacol Sci. 2022 May;149(1):1-10.