TPNA10168

Modify Date: 2024-03-01 18:38:47

TPNA10168 structure	Common Name	TPNA10168
	CAS Number	957942-34-6	Molecular Weight	248.75
	Density	1.54±0.1 g/cm3 (20 °C, 760 mmHg)	Boiling Point	490.3±45.0 °C (760 mmHg)
	Molecular Formula	C₉H₉ClO₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TPNA10168

TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases[1].

Name	Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-3-(methylsulfinyl)
Synonym	More Synonyms

Description	TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
References	[1]. Izumi Y, et al. TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway. J Pharmacol Sci. 2022 May;149(1):1-10.

Density	1.54±0.1 g/cm3 (20 °C, 760 mmHg)
Boiling Point	490.3±45.0 °C (760 mmHg)
Molecular Formula	C₉H₉ClO₂S₂
Molecular Weight	248.75
Exact Mass	247.97300
PSA	81.59000
LogP	3.52360

1-chloro-3-(methylsulfinyl)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one

TPNA10168

Use of TPNA10168

Names

TPNA10168 Biological Activity

Chemical & Physical Properties

Synonyms