77739-21-0

77739-21-0 structure

Name: b-Neo-Endorphin
Chemical Name: β-Neoendorphin
CAS Number: 77739-21-0
Molecular Formula: C₅₄H₇₇N₁₃O₁₂
Molecular Weight: 1100.27000
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2017-08-30 02:10:37
Modify Date: 2024-01-08 23:02:35
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9[1][2].

Name	β-Neoendorphin
Synonyms	L-Proline, L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-tyrosyl- L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-tyrosyl-L-proline β-Neoendorphin β-neo-endorphin b-Neo-Endorphin

Description	β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9[1][2].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK1 ERK2 MMP-2 MMP-9
In Vitro	β-Neo-Endorphin (0-20 μM, 20 h) stimulates wound healing in human keratinocytes[2]. β-Neo-Endorphin (promotes wound healing through activation of the Erk1/2 signaling pathway in human keratinocytes[2]. β-Neo-Endorphin (0-20 μM, 12 h) stimulates keratinocyte migration through activation of metalloproteinase (MMP)-2 and -9[2]. β-Neo-Endorphin (12 h) stimulates migration in the fibroblast[2]. Cell Viability Assay[2] Cell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 20 h Result: Significantly increased the wound closure. Had no observable effect on cell viability. Western Blot Analysis[2] Cell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 12 h Result: Activated Erk1/2, phosphorylated P90RSK and Elk-1, showed significant upregulation of MMP-2 and -9 expression.