13997-19-8

13997-19-8 structure

Name: Nequinate
Chemical Name: Methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS Number: 13997-19-8
Molecular Formula: C₂₂H₂₃NO₄
Molecular Weight: 365.422
Catalog: API Veterinary drug raw materials
Create Date: 2018-05-30 08:00:00
Modify Date: 2024-01-04 13:49:55
Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].

Name	Methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
Synonyms	7-(Benzyloxy)-6-n-butyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Methyl Ester 7-(Benzyloxy)-6-n-butyl-3-methoxycarbonyl-4-quinolone nequinate MFCD00867198 methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate Methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate EINECS 237-796-6 3-Quinolinecarboxylic acid, 6-butyl-1,4-dihydro-4-oxo-7-(phenylmethoxy)-, methyl ester 7-(Benzyloxy)-6-n-butyl-4-hydroxy-3-quinolinecarboxylic Acid Methyl Ester 3-Methoxycarbonyl-6-n-butyl-7-benzyloxy-4-oxoquinoline

Description	Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].
Related Catalog	Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
In Vitro	Xanthine oxidase (XOD) is a successful and safe drug target for lowering lower serum urate (sUA) levels , it plays an important role in the catabolism of purine Nequinate shows an inhibition of 12.0% to inhibit XOD activities[2].
References	[1]. D K McLoughlin, et al.Efficacy of Nequinate Against Thirteen Strains of Eimeria Tenella and the Development of a Nequinate-Resistant Strain.Avian Dis. Oct-Dec 1973;17(4):717-21. [2]. Yanfen Niu, et al. Old Drug, New Indication: Olsalazine Sodium Reduced Serum Uric Acid Levels in Mice via Inhibiting Xanthine Oxidoreductase Activity. J Pharmacol Sci. 2017 Nov;135(3):114-120.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H413
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
RIDADR	NONH for all modes of transport
HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%