Nequinate

Modify Date: 2024-01-04 13:49:55

Nequinate Structure
Nequinate structure
Common Name Nequinate
CAS Number 13997-19-8 Molecular Weight 365.422
Density 1.2±0.1 g/cm3 Boiling Point 520.7±50.0 °C at 760 mmHg
Molecular Formula C22H23NO4 Melting Point 287.5ºC
MSDS Chinese USA Flash Point 268.7±30.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Nequinate


Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].

 Names

Name Methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
Synonym More Synonyms

 Nequinate Biological Activity

Description Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].
Related Catalog
In Vitro Xanthine oxidase (XOD) is a successful and safe drug target for lowering lower serum urate (sUA) levels , it plays an important role in the catabolism of purine Nequinate shows an inhibition of 12.0% to inhibit XOD activities[2].
References

[1]. D K McLoughlin, et al.Efficacy of Nequinate Against Thirteen Strains of Eimeria Tenella and the Development of a Nequinate-Resistant Strain.Avian Dis. Oct-Dec 1973;17(4):717-21.

[2]. Yanfen Niu, et al. Old Drug, New Indication: Olsalazine Sodium Reduced Serum Uric Acid Levels in Mice via Inhibiting Xanthine Oxidoreductase Activity. J Pharmacol Sci. 2017 Nov;135(3):114-120.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 520.7±50.0 °C at 760 mmHg
Melting Point 287.5ºC
Molecular Formula C22H23NO4
Molecular Weight 365.422
Flash Point 268.7±30.1 °C
Exact Mass 365.162720
PSA 68.39000
LogP 6.01
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.579

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H413
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
RIDADR NONH for all modes of transport
HS Code 2933499090

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles10

More Articles
Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials.

Vet. Parasitol. 76(3) , 163-71, (1998)

Coccidia were isolated from a commercial broiler farm with a history of suspected drug resistance. The sensitivity profiles of the Eimeria spp. isolates against the anticoccidial drugs nicarbazin (NIC...

Sensitivity of field isolates of Eimeria tenella to anticoccidial drugs in the chicken.

Res. Vet. Sci. 47(1) , 125-8, (1989)

Thirty isolates of Eimeria tenella obtained from broiler and breeder farms were examined for their sensitivity to anticoccidial drugs. All were sensitive to robenidine, 28 were sensitive to methyl ben...

Immunity and effect of clopidol/methyl benzoquate and robenidine before and after weaning on rabbit coccidiosis in the field.

Res. Vet. Sci. 35(2) , 211-6, (1983)

For 15 months the anticoccidial effect of 200 ppm clopidol/methyl benzoquate and of 50 ppm robenidine, and the development of immunity against five different species of Eimeria were followed in a clos...

 Synonyms

7-(Benzyloxy)-6-n-butyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Methyl Ester
7-(Benzyloxy)-6-n-butyl-3-methoxycarbonyl-4-quinolone
nequinate
MFCD00867198
methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
Methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate
EINECS 237-796-6
3-Quinolinecarboxylic acid, 6-butyl-1,4-dihydro-4-oxo-7-(phenylmethoxy)-, methyl ester
7-(Benzyloxy)-6-n-butyl-4-hydroxy-3-quinolinecarboxylic Acid Methyl Ester
3-Methoxycarbonyl-6-n-butyl-7-benzyloxy-4-oxoquinoline
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