Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-CARBAMOYL-1-((2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIDIN-1-IUM
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Purity: 98.0%
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1341-23-7

1341-23-7 structure

Name: Nicotinamide Riboside
Chemical Name: N-ribosylnicotinamide
CAS Number: 1341-23-7
Molecular Formula: C₁₁H₁₅N₂O₅
Molecular Weight: 255.247
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2018-09-03 17:02:34
Modify Date: 2024-01-03 15:58:41
Nicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1].

Name	N-ribosylnicotinamide
Synonyms	Pyridinium, 3-(aminocarbonyl)-1-β-D-ribofuranosyl- Nicotinamide riboside-oxidized form 3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium Nicotinamide Ribose 3-(Aminocarbonyl)-1beta-D-ribofuranosylpyridinium 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridine-5-carboxamide NRH-oxidized form 3-(aminocarbonyl)-1-β-D-ribofuranosyl-Pyridinium Nicotinamide riboside N-ribosylnicotinamid

Description	Nicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT1 SIRT3
In Vitro	Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2.
In Vivo	Chronic Nicotinamide riboside (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner.
References	[1]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.

Hazard Codes	Xn

98-92-0

13035-61-5

1341-23-7