1341-23-7
1341-23-7 structure
- Name: Nicotinamide Riboside
- Chemical Name: N-ribosylnicotinamide
- CAS Number: 1341-23-7
- Molecular Formula: C11H15N2O5
- Molecular Weight: 255.247
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2018-09-03 17:02:34
- Modify Date: 2026-06-30 22:26:20
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Nicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1].
| Name | N-ribosylnicotinamide |
|---|---|
| Synonyms |
Nicotinamide Ribose NR
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-cboxamide 3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium 3-(AMinocbonyl)-1beta-D-ribofuranosylpyridiniuM Nicotinamide Ribose1-7 Nicotinamide Ribos,NR NRH-oxidized form Nicotinimide Riboside NR(Nicotinamide Riboside) Pyridin-3-cboxamide riboside β-Nicotinamide Riboside Nicotinamide Riboside (Contain ~ food ade dextrin as stabilizer) 3-(Aminocbonyl)-1-β-D-ribofuranosylpyridinium 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridine-5-cboxamide 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridine-5-carboxamide Nicotiamide Riboside C:C&B64 3-(aminocarbonyl)-1-β-D-ribofuranosyl-Pyridinium Nicotinamide ribonucleoside NICOTINAMIDE RIBOSIDE Basic information Nicotinamide riboside-oxidized form Nicotinamide Ribose Beta-Nicotinamide Riboside beta-Nicotinamide riboside triflic acid salt Pyridinium, 3-(aminocbonyl)-1-β-D-ribofuranosyl Nicotinamide riboside 3-Cbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium BETA-nicotinamide ribose N-ribosylnicotinamid Nicotinamide riboside / NRC /Nicotinamide riboside chloride NR(nicotinamide ribose) Niacinamide Ribose Pyridinium,3-(aminocbonyl)-1-b-D-ribofuranosyl 3-(Aminocarbonyl)-1beta-D-ribofuranosylpyridinium NR/ Nicotinamide Riboside (anti-aging) NICOTINAMIDE RIBOSIDE(R)-5-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)cyclohexa-1,3-dienecboxamide nicotinamide-beta-riboside Nicotinamide riboside (NR) |
| Description | Nicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1]. |
|---|---|
| Related Catalog | |
| Target |
SIRT1 SIRT3 |
| In Vitro | Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2. |
| In Vivo | Chronic Nicotinamide riboside (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner. |
| References |
| Density | 1.201g/cm3 |
|---|---|
| Boiling Point | 353.7ºC at 760mmHg |
| Molecular Formula | C11H15N2O5 |
| Molecular Weight | 255.247 |
| Flash Point | 181.9ºC |
| Exact Mass | 255.097549 |
| PSA | 116.25000 |
| LogP | -2.30 |
| Vapour Pressure | 3.05E-07mmHg at 25°C |
| Index of Refraction | 1.549 |
| Hazard Codes | Xn |
|---|
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~%
1341-23-7 |
| Literature: Angewandte Chemie - International Edition, , vol. 43, # 35 p. 4637 - 4640 |
| Precursor 2 | |
|---|---|
| DownStream 1 | |