362-05-0

362-05-0 structure

Name: 2-Hydroxyestradiol
Chemical Name: 2-hydroxy-17β-estradiol
CAS Number: 362-05-0
Molecular Formula: C₁₈H₂₄O₃
Molecular Weight: 288.38
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Methylpyridine
Create Date: 2018-12-31 15:36:19
Modify Date: 2024-01-09 07:41:56
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].

Name	2-hydroxy-17β-estradiol
Synonyms	Estra-1,3,5(10)-triene-2,3,17β-triol 2-Hydroxy-17b-estradiol 2-hydroxy-17β-estradiol 2-hydroxy-17beta-estradiol MFCD00010490 (17β)-Estra-1(10),2,4-triene-2,3,17-triol Estra-1,3,5(10)-triene-2,3,17-triol, (17β)- 2-Hydroxyestradiol 2,3,17b-Trihydroxyestra-1,3,5(10)-triene estra-1(10),2,4-triene-2,3,17-triol, (17β)- Estra-1,3,5(10)-triene-2,3,17-β-triol (17b)-Estra-1(10),2,4-triene-2,3,17-triol (17β)-Estra-1,3,5(10)-triene-2,3,17-triol 2-hydroxy-estradiol 2-Oh-estradiol Estra-1,3,5(10)-triene-2,3,17b-triol 2-Hydroxy-17-estradiol

Description	2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	2-Hydroxyestradiol induces phenotypical changes indicative of neoplastic transformation[1]. 2-Hydroxyestradiol (2-OHE2) is capable of in vitro transforming a HBEC, MCF-10F cell line, that is estrogen receptor-a (ERα) negative and ERβ positive[1]. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells[3].
In Vivo	2-Hydroxyestradiol attenuated the development of obesity and improved endothelial function, decreased nephropathy, decreased the severity of diabetes, lowered arterial blood pressure, and reduced plasma cholesterol[2].
References	[1]. C H Van Aswegen, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92. [2]. S P Tofovic, et al. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther. 2001 Dec;299(3):973-7. [3]. Yeon-Jin Hurh, et al. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J Toxicol Environ Health A. 2004 Dec;67(23-24):1939-53.

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male Endocrine - androgenic

REFERENCE :: ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year: 23,339,1991

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 42,165,1986

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P281
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	40
Safety Phrases	S22;S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG7675000